Cyclosporine Ophthalmic

545 interactions 1,631 cited references
Also sold as: Cequa Cequa® Restasis® Vevye
About Cyclosporine Ophthalmic

Ophthalmic cyclosporine is used to increase tear production in people with dry eye disease. Cyclosporine is in a class of medications called immunomodulators. It works by decreasing swelling in the eye to allow for tear production. Read the full Cyclosporine Ophthalmic drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Cyclosporine Ophthalmic Bedaquiline Sirturo Increased bedaquiline exposure Details Cyclosporine Ophthalmic Belumosudil Rezurock Increased P-gp substrate exposure Details Cyclosporine Ophthalmic Belzutifan Welireg Reduced CYP3A4 substrates with NTI exposure and reduced efficacy of CYP3A4 substrates with NTI Details Cyclosporine Ophthalmic Benazepril Lotensin Acute renal dysfunction and an increased risk of hyperkalemia Details Cyclosporine Ophthalmic Benzhydrocodone Increased HYDROcodone exposure and risk of increased or prolonged opioid effects Details Cyclosporine Ophthalmic Berotralstat Orladeyo Increased CYP3A4/P-gp substrate exposure Details Cyclosporine Ophthalmic Betrixaban Bevyxxa® Increased betrixaban exposure and increased risk of bleeding Details Cyclosporine Ophthalmic Bezafibrate Increased risk of renal dysfunction Details Cyclosporine Ophthalmic Bimekizumab-Bkzx Altered cycloSPORINE exposure Details Cyclosporine Ophthalmic Black Cohosh Reduced immunosuppressive drug effectiveness and acute transplant rejection Details Cyclosporine Ophthalmic Boceprevir Increased cycloSPORINE exposure Details Cyclosporine Ophthalmic Bosutinib Bosulif Increased bosutinib exposure Details Cyclosporine Ophthalmic Brigatinib Alunbrig Increased brigatinib exposure Details Cyclosporine Ophthalmic Bromfenac Bromsite An increased risk of cycloSPORINE nephrotoxicity Details Cyclosporine Ophthalmic Bromocriptine Cycloset Increased cycloSPORINE exposure Details Cyclosporine Ophthalmic Budesonide Entocort Increased budesonide exposure Details Cyclosporine Ophthalmic Bufexamac An increased risk of cycloSPORINE nephrotoxicity Details Cyclosporine Ophthalmic Buprenorphine Belbuca Increased buprenorphine exposure and an increased risk of buprenorphine-related adverse events Details Cyclosporine Ophthalmic Bupropion Aplenzin Increased risk of seizures Details Cyclosporine Ophthalmic Canagliflozin Invokana Increased cycloSPORINE exposure Details Cyclosporine Ophthalmic Candesartan Atacand An increased risk of hyperkalemia Details Cyclosporine Ophthalmic Canrenoate An increased risk of hyperkalemia Details Cyclosporine Ophthalmic Canrenone An increased risk of hyperkalemia Details Cyclosporine Ophthalmic Capivasertib Truqap Increased capivasertib exposure and an increased risk of capivasertib-related adverse reactions Details Cyclosporine Ophthalmic Capmatinib Tabrecta Increased cycloSPORINE exposure Details Cyclosporine Ophthalmic Captopril Capoten® Acute renal dysfunction, increased risk of hyperkalemia and an increased cycloSPORINE exposure Details Cyclosporine Ophthalmic Carbamazepine Carbatrol Reduced cycloSPORINE exposure Details Cyclosporine Ophthalmic Caspofungin Increased plasma levels of caspofungin and increased risk of hepatic enzyme elevations Details Cyclosporine Ophthalmic Celecoxib Celebrex An increased risk of cycloSPORINE nephrotoxicity Details Cyclosporine Ophthalmic Cenobamate Xcopri Reduced cycloSPORINE exposure Details Cyclosporine Ophthalmic Ceritinib Zykadia Increased exposure of CYP3A substrate Details Cyclosporine Ophthalmic Cerivastatin An increased risk of myopathy or rhabdomyolysis Details Cyclosporine Ophthalmic Cholera Vaccine, Live An inadequate immunological response to the vaccine, increased risk of disseminated infection with live vaccines and reduced effic... Details Cyclosporine Ophthalmic Cholic Acid Exacerbation of bile salt accumulation in the liver; increased clinical symptoms Details Cyclosporine Ophthalmic Choline Salicylate An increased risk of cycloSPORINE nephrotoxicity Details Cyclosporine Ophthalmic Cimetidine Tagamet An increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) Details Cyclosporine Ophthalmic Ciprofibrate Increased risk of renal dysfunction Details Cyclosporine Ophthalmic Ciprofloxacin Increased risk of renal dysfunction and an increased cycloSPORINE exposure Details Cyclosporine Ophthalmic Clarithromycin Biaxin Increased cycloSPORINE exposure Details Cyclosporine Ophthalmic Clofazimine Increased cycloSPORINE exposure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.