Cyclosporine Ophthalmic

545 interactions 1,631 cited references
Also sold as: Cequa Cequa® Restasis® Vevye
About Cyclosporine Ophthalmic

Ophthalmic cyclosporine is used to increase tear production in people with dry eye disease. Cyclosporine is in a class of medications called immunomodulators. It works by decreasing swelling in the eye to allow for tear production. Read the full Cyclosporine Ophthalmic drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Cyclosporine Ophthalmic Felbinac An increased risk of cycloSPORINE nephrotoxicity Details Cyclosporine Ophthalmic Felodipine Plendil® Increased felodipine exposure, increased risk of felodipine toxicity and increased cycloSPORINE exposure Details Cyclosporine Ophthalmic Fenofibrate Antara An increased risk of nephrotoxicity with reduced creatine clearance and an increased risk of renal function deterioration Details Cyclosporine Ophthalmic Fenofibric Acid Fibricor An increased risk of nephrotoxicity with reduced creatine clearance and an increased risk of renal function deterioration Details Cyclosporine Ophthalmic Fenoprofen Fenopron An increased risk of cycloSPORINE nephrotoxicity Details Cyclosporine Ophthalmic Fentanyl Increased fentaNYL exposure and an increased risk of prolonged opioid effects Details Cyclosporine Ophthalmic Fepradinol An increased risk of cycloSPORINE nephrotoxicity Details Cyclosporine Ophthalmic Feprazone An increased risk of cycloSPORINE nephrotoxicity Details Cyclosporine Ophthalmic Fexinidazole Decreased exposure of active fexinidazole metabolites; potential decreased efficacy of fexinidazole; increased adverse effects of... Details Cyclosporine Ophthalmic Finerenone Kerendia Increased finerenone exposure and an increased risk of finerenone-related adverse effects Details Cyclosporine Ophthalmic Flibanserin Addyi Increased cycloSPORINE exposure Details Cyclosporine Ophthalmic Floctafenine An increased risk of cycloSPORINE nephrotoxicity Details Cyclosporine Ophthalmic Fluconazole Diflucan Increased cycloSPORINE exposure and an increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) Details Cyclosporine Ophthalmic Flufenamic Acid An increased risk of cycloSPORINE nephrotoxicity Details Cyclosporine Ophthalmic Flurbiprofen Ansaid An increased risk of cycloSPORINE nephrotoxicity Details Cyclosporine Ophthalmic Fluvastatin Lescol Increased fluvastatin exposure and an increased risk of myopathy or rhabdomyolysis Details Cyclosporine Ophthalmic Fluvoxamine Increased cycloSPORINE exposure and an increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) Details Cyclosporine Ophthalmic Fosamprenavir Lexiva Increased cycloSPORINE exposure Details Cyclosporine Ophthalmic Fosaprepitant Emend Injection Increased cycloSPORINE exposure Details Cyclosporine Ophthalmic Foscarnet Foscavir Nephrotoxicity Details Cyclosporine Ophthalmic Fosinopril Monopril® Acute renal dysfunction and an increased risk of hyperkalemia Details Cyclosporine Ophthalmic Fosnetupitant Increased exposure of CYP3A4 substrate Details Cyclosporine Ophthalmic Fosphenytoin Cerebyx Reduced cycloSPORINE exposure and potentially increased risk of organ rejection Details Cyclosporine Ophthalmic Fostamatinib Tavalisse Increased cycloSPORINE exposure Details Cyclosporine Ophthalmic Gemfibrozil Lopid Increased risk of renal dysfunction Details Cyclosporine Ophthalmic Gentamicin An increased risk of nephrotoxicity and increased risk of renal dysfunction Details Cyclosporine Ophthalmic Gepirone Exxua Increased gepirone exposure and an increased risk of gepirone-related adverse effects Details Cyclosporine Ophthalmic Gepotidacin Blujepa Increased CYP3A4 substrate with NTI exposure Details Cyclosporine Ophthalmic Gestodene Increased cycloSPORINE exposure and an increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) Details Cyclosporine Ophthalmic Gilteritinib Xospata Increased P-gp substrate exposure and increased incidence and severity of adverse reactions associated with the P-gp substrate Details Cyclosporine Ophthalmic Givinostat Duvyzat Increased CYP3A4 substrate exposure and an increased risk of CYP3A4 substrate-related adverse effects and toxicity Details Cyclosporine Ophthalmic Glecaprevir Increased glecaprevir exposure and an increased cycloSPORINE exposure Details Cyclosporine Ophthalmic Haloperidol Increased haloperidol exposure and an increased risk of haloperidol-related adverse events, including QTc interval prolongation Details Cyclosporine Ophthalmic Hydrocodone Hysingla Increased HYDROcodone exposure and risk of increased or prolonged opioid effects Details Cyclosporine Ophthalmic Hydrocortisone Ala-Cort Increased hydrocortisone exposure, an increased cycloSPORINE exposure and an increased risk of convulsions Details Cyclosporine Ophthalmic Hydroxychloroquine Plaquenil Increased cycloSPORINE exposure and an increased risk of seizures Details Cyclosporine Ophthalmic Ibrexafungerp Brexafemme Increased cycloSPORINE exposure Details Cyclosporine Ophthalmic Ibrutinib Imbruvica Increased ibrutinib exposure Details Cyclosporine Ophthalmic Ibuprofen Addaprin An increased risk of cycloSPORINE nephrotoxicity Details Cyclosporine Ophthalmic Idelalisib Zydelig Increased cycloSPORINE exposure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.