Cyclosporine Ophthalmic

545 interactions 1,631 cited references
Also sold as: Cequa Cequa® Restasis® Vevye
About Cyclosporine Ophthalmic

Ophthalmic cyclosporine is used to increase tear production in people with dry eye disease. Cyclosporine is in a class of medications called immunomodulators. It works by decreasing swelling in the eye to allow for tear production. Read the full Cyclosporine Ophthalmic drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Cyclosporine Ophthalmic Maribavir Livtencity Increased cycloSPORINE exposure and an increased cycloSPORINE-related adverse events Details Cyclosporine Ophthalmic Mavorixafor Xolremdi Increased cycloSPORINE exposure, increased mavorixafor exposure, increased risk of cycloSPORINE-related adverse events and an incr... Details Cyclosporine Ophthalmic Measles Virus Vaccine, Live An inadequate immunological response to the vaccine, increased risk of disseminated infection with live vaccines and reduced effic... Details Cyclosporine Ophthalmic Meclofenamate Meclodium® An increased risk of cycloSPORINE nephrotoxicity Details Cyclosporine Ophthalmic Mefenamic Acid Ponstel® An increased risk of cycloSPORINE nephrotoxicity Details Cyclosporine Ophthalmic Meloxicam Alloxate An increased risk of cycloSPORINE nephrotoxicity Details Cyclosporine Ophthalmic Melphalan Alkeran An increased risk of severe renal failure Details Cyclosporine Ophthalmic Meperidine Demerol Increased meperidine exposure and risk of increased or prolonged opioid effects Details Cyclosporine Ophthalmic Mercaptopurine Purinethol® Reduced cycloSPORINE exposure and an increased risk of hepatotoxicity Details Cyclosporine Ophthalmic Mestranol Increased cycloSPORINE exposure and an increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) Details Cyclosporine Ophthalmic Methadone Diskets Increased methadone exposure and an increased risk of opioid adverse effects Details Cyclosporine Ophthalmic Methotrexate Jylamvo Increased methotrexate exposure, potentiation of methotrexate efficacy, methotrexate toxicity or methotrexate-related severe adver... Details Cyclosporine Ophthalmic Methylergonovine Methergine Increased methylergonovine exposure Details Cyclosporine Ophthalmic Methylprednisolone Depo-Medrol Increased cycloSPORINE exposure, increased cycloSPORINE toxicity and steroid excess Details Cyclosporine Ophthalmic Metoclopramide Increased cycloSPORINE exposure and an increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) Details Cyclosporine Ophthalmic Mibefradil Increased cycloSPORINE exposure and an increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) Details Cyclosporine Ophthalmic Mirabegron Myrbetriq Increased cycloSPORINE exposure Details Cyclosporine Ophthalmic Mitapivat Aqvesme Increased P-gp substrate exposure; reduced CYP3A substrate exposure Details Cyclosporine Ophthalmic Mitotane Lysodren Reduced CYP3A substrate with NTI exposure and reduced efficacy of CYP3A substrate with NTI exposure Details Cyclosporine Ophthalmic Mobocertinib Exkivity Decreased plasma concentrations of the CYP3A substrate, which may result in serious therapeutic failure Details Cyclosporine Ophthalmic Modafinil Provigil Reduced cycloSPORINE exposure and reduced efficacy of cycloSPORINE Details Cyclosporine Ophthalmic Moexipril Univasc® Acute renal dysfunction and an increased risk of hyperkalemia Details Cyclosporine Ophthalmic Momelotinib Ojjaara Increased momelotinib exposure and an increased risk of momelotinib-related adverse reactions Details Cyclosporine Ophthalmic Morniflumate An increased risk of cycloSPORINE nephrotoxicity Details Cyclosporine Ophthalmic Morphine Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Cyclosporine Ophthalmic Morphine Sulfate Liposome Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Cyclosporine Ophthalmic Mumps Virus Vaccine, Live An inadequate immunological response to the vaccine, increased risk of disseminated infection with live vaccines and reduced effic... Details Cyclosporine Ophthalmic Mycophenolate Mofetil Reduced mycophenolic acid (MPA) exposure and reduced efficacy of mycophenolate mofetil Details Cyclosporine Ophthalmic Mycophenolic Acid Myfortic Decreased mycophenolic acid or mycophenolic sodium plasma concentrations Details Cyclosporine Ophthalmic Nabumetone Relafen An increased risk of cycloSPORINE nephrotoxicity Details Cyclosporine Ophthalmic Nafcillin Reduced cycloSPORINE exposure Details Cyclosporine Ophthalmic Naproxen Aleve An increased risk of cycloSPORINE nephrotoxicity Details Cyclosporine Ophthalmic Nefazodone Increased cycloSPORINE exposure and an increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) Details Cyclosporine Ophthalmic Nelfinavir Viracept Increased cycloSPORINE exposure and an increased nelfinavir exposure Details Cyclosporine Ophthalmic Nemolizumab-Ilto Increased cycloSPORINE exposure Details Cyclosporine Ophthalmic Nepafenac Ilevro An increased risk of cycloSPORINE nephrotoxicity Details Cyclosporine Ophthalmic Neratinib Nerlynx Increased neratinib exposure, an increased risk of neratinib toxicity and an increased cycloSPORINE exposure Details Cyclosporine Ophthalmic Netupitant Increased exposure of CYP3A4 substrate Details Cyclosporine Ophthalmic Nevirapine Viramune Reduced cycloSPORINE exposure Details Cyclosporine Ophthalmic Nicardipine Cardene Increased cycloSPORINE exposure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.