Cyclosporine

174 interactions 14 explained in plain English
Also sold as: Atopica Cequa Cyclavance Gengraf Modulis Neoral Optimmune Restasis Sandimmune Sporimune Verkazia Vevye
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ezetimibe Colchicine Simvastatin Perindopril Meclofenamate Buprenorphine
3 Contraindicated 132 Major 39 Moderate
All (174) Contraindicated (3) Major (132) Moderate (39)

Moderate

Cyclosporine Fluoxymesterone Android-F® An increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) Details Cyclosporine Furosemide Injection Disal Increased risk of gouty arthritis secondary to furosemide-induced hyperuricemia and cyclosporine impairment of renal urate excreti... Details Cyclosporine Glipizide Glucotrol An increased risk of cyclosporine toxicity (renal dysfunction, cholestasis, paresthesias) Details Cyclosporine Golimumab Injection Simponi Increased cycloSPORINE exposure Details Cyclosporine Metronidazole Flagyl An increased risk of cycloSPORINE toxicity (nephrotoxicity, cholestasis, paresthesias) Details Cyclosporine Metronidazole Injection Flagyl An increased risk of cycloSPORINE toxicity (nephrotoxicity, cholestasis, paresthesias) Details Cyclosporine Metronidazole Topical MetroCream® An increased risk of cycloSPORINE toxicity (nephrotoxicity, cholestasis, paresthesias) Details Cyclosporine Metronidazole Vaginal MetroGel® Vaginal An increased risk of cycloSPORINE toxicity (nephrotoxicity, cholestasis, paresthesias) Details Cyclosporine Miconazole Buccal Oravig An increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) Details Cyclosporine Miconazole Topical Aloe Vesta Antifungal An increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) Details Cyclosporine Miconazole Vaginal Lagicam An increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) Details Cyclosporine Miconazole Aloe Vesta Antifungal An increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) Details Cyclosporine Midazolam Nasal Spray Nayzilam Decreased midazolam clearance and increased midazolam plasma concentrations Details Cyclosporine Midazolam Injection Nayzilam Decreased midazolam clearance and increased midazolam plasma concentrations Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.