Dabigatran

284 interactions 383 cited references

Also sold as: Pradaxa®

About Dabigatran

Dabigatran is a direct thrombin inhibitor anticoagulant used to treat blood clots and prevent strokes in patients with irregular heartbeats. Read the full Dabigatran drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Levoketoconazole Defibrotide Zanubrutinib Ensitrelvir Enoxaparin Enasidenib

2 Contraindicated 253 Major 29 Moderate

All (284) Contraindicated (2) Major (253) Moderate (29)

Major

Dabigatran Cilostazol Pletal® Increased risk of bleeding Details Dabigatran Cimetidine Tagamet Increased dabigatran exposure and an increased risk of bleeding Details Dabigatran Citalopram Celexa An increased risk of bleeding Details Dabigatran Clarithromycin Biaxin Increased dabigatran exposure and an increased risk of bleeding Details Dabigatran Clonixin An increased risk of bleeding Details Dabigatran Clopidogrel Plavix An increased risk of bleeding Details Dabigatran Cobicistat Tybost Increased dabigatran exposure and an increased risk of bleeding Details Dabigatran Collagenase, Clostridium Histolyticum Increased risk of bleeding adverse effects Details Dabigatran Conivaptan Vaprisol Increased dabigatran exposure and an increased risk of bleeding Details Dabigatran Crizotinib Xalkori Increased dabigatran etexilate exposure Details Dabigatran Cyclosporine Atopica Increased dabigatran exposure Details Dabigatran Daclatasvir Daklinza® Increased dabigatran exposure and an increased risk of bleeding Details Dabigatran Dalteparin Fragmin An increased risk of bleeding Details Dabigatran Danaparoid An increased risk of bleeding Details Dabigatran Daridorexant Increased dabigatran exposure and an increased risk of bleeding Details Dabigatran Desirudin Iprivask An increased risk of bleeding Details Dabigatran Desvenlafaxine Pristiq An increased risk of bleeding Details Dabigatran Dexibuprofen An increased risk of bleeding Details Dabigatran Dexketoprofen An increased risk of bleeding Details Dabigatran Diclofenac Aleve Arthritis Pain An increased risk of bleeding Details Dabigatran Diflunisal Dolobid An increased risk of bleeding Details Dabigatran Diltiazem Cardizem Increased dabigatran exposure and an increased risk of bleeding Details Dabigatran Dipyridamole Permole® Increased risk of bleeding Details Dabigatran Dipyrone An increased risk of bleeding Details Dabigatran Donanemab-Azbt An increased risk of amyloid related imaging abnormalities (ARIA), or intracerebral hemorrhage Details Dabigatran Doxorubicin Adriamycin Reduced dabigatran etexilate exposure Details Dabigatran Doxycycline Acticlate An increased risk of bleeding Details Dabigatran Dronedarone Multaq Increased dabigatran exposure and an increased risk of bleeding Details Dabigatran Droxicam An increased risk of bleeding Details Dabigatran Edoxaban Savaysa Increased risk of bleeding Details Dabigatran Efavirenz Reduced dabigatran exposure, reduced efficacy of dabigatran and an increased risk of thrombosis Details Dabigatran Elacestrant Orserdu Increased dabigatran exposure and an increased risk of bleeding Details Dabigatran Elagolix Orilissa Increased dabigatran exposure and an increased risk of bleeding Details Dabigatran Eliglustat Cerdelga Increased dabigatran exposure and an increased risk of bleeding Details Dabigatran Enasidenib Idhifa Increased dabigatran exposure and an increased risk of bleeding Details Dabigatran Enoxaparin Lovenox An increased risk of bleeding Details Dabigatran Ensitrelvir Increased risk of P-gp substrate exposure Details Dabigatran Entrectinib Rozlytrek Increased dabigatran exposure and an increased risk of bleeding Details Dabigatran Enzalutamide Xtandi Increased dabigatran exposure and an increased risk of bleeding Details Dabigatran Epoprostenol Flolan Increased risk of bleeding Details

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