Dabigatran

284 interactions 383 cited references
Also sold as: Pradaxa®
About Dabigatran

Dabigatran is a direct thrombin inhibitor anticoagulant used to treat blood clots and prevent strokes in patients with irregular heartbeats. Read the full Dabigatran drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Levoketoconazole Defibrotide Zanubrutinib Ensitrelvir Enoxaparin Enasidenib
2 Contraindicated 253 Major 29 Moderate
All (284) Contraindicated (2) Major (253) Moderate (29)

Major

Dabigatran Parecoxib Increased risk of bleeding Details Dabigatran Parnaparin An increased risk of bleeding Details Dabigatran Paroxetine Paxil Increased dabigatran exposure and an increased risk of bleeding Details Dabigatran Pentosan Polysulfate Sodium An increased risk of bleeding Details Dabigatran Pexidartinib Turalio Increased dabigatran exposure and an increased risk of bleeding Details Dabigatran Phenindione An increased risk of bleeding Details Dabigatran Phenobarbital Fidoquel Reduced dabigatran exposure and increased risk of thrombotic events Details Dabigatran Phenprocoumon An increased risk of bleeding Details Dabigatran Phenylbutazone Equi-Phar An increased risk of bleeding Details Dabigatran Phenytoin Dilantin Reduced dabigatran exposure Details Dabigatran Pibrentasvir Increased dabigatran exposure and an increased risk of bleeding Details Dabigatran Piketoprofen An increased risk of bleeding Details Dabigatran Piperacillin An increased risk of bleeding Details Dabigatran Piracetam Increased risk of bleeding Details Dabigatran Piroxicam Feldene An increased risk of bleeding Details Dabigatran Pirtobrutinib Jaypirca Increased dabigatran exposure and an increased risk of bleeding Details Dabigatran Pranoprofen An increased risk of bleeding Details Dabigatran Prasugrel Effient Increased risk of bleeding Details Dabigatran Primidone Mysoline Reduced dabigatran exposure and increased risk of thrombotic events Details Dabigatran Proglumetacin An increased risk of bleeding Details Dabigatran Propafenone Rythmol Increased dabigatran exposure and an increased risk of bleeding Details Dabigatran Propyphenazone An increased risk of bleeding Details Dabigatran Proquazone An increased risk of bleeding Details Dabigatran Protein C Ceprotin An increased risk of bleeding Details Dabigatran Quinidine Cardioquin® Increased dabigatran exposure and an increased risk of bleeding Details Dabigatran Quinine Increased dabigatran exposure and an increased risk of bleeding Details Dabigatran Ranolazine Aspruzyo Increased dabigatran exposure and an increased risk of bleeding Details Dabigatran Remibrutinib Rhapsido An increased risk of bleeding Details Dabigatran Reteplase, Recombinant An increased risk of bleeding Details Dabigatran Reviparin An increased risk of bleeding Details Dabigatran Rifabutin Mycobutin Reduced dabigatran exposure, reduced efficacy of dabigatran and an increased risk of thrombosis Details Dabigatran Rifampin Rifadin Reduced dabigatran exposure, reduced efficacy of dabigatran and an increased risk of thrombosis Details Dabigatran Ritonavir Norvir Increased dabigatran exposure and an increased risk of bleeding Details Dabigatran Rivaroxaban Xarelto An increased risk of bleeding Details Dabigatran Rofecoxib An increased risk of bleeding Details Dabigatran Rolapitant Varubi Increased dabigatran exposure and an increased risk of bleeding Details Dabigatran Rucaparib Rubraca Increased dabigatran exposure and an increased risk of bleeding Details Dabigatran Saquinavir Increased dabigatran exposure and an increased risk of bleeding Details Dabigatran Sarecycline Seysara Increased dabigatran exposure and an increased risk of bleeding Details Dabigatran Selexipag Uptravi Increased risk of bleeding Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.