Dabigatran

284 interactions 383 cited references

Also sold as: Pradaxa®

About Dabigatran

Dabigatran is a direct thrombin inhibitor anticoagulant used to treat blood clots and prevent strokes in patients with irregular heartbeats. Read the full Dabigatran drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Levoketoconazole Defibrotide Zanubrutinib Ensitrelvir Enoxaparin Enasidenib

2 Contraindicated 253 Major 29 Moderate

All (284) Contraindicated (2) Major (253) Moderate (29)

Major

Dabigatran Sertraline An increased risk of bleeding Details Dabigatran Simeprevir Olysio® Increased dabigatran exposure and an increased risk of bleeding Details Dabigatran Sofosbuvir Sovaldi Increased dabigatran exposure and an increased risk of bleeding Details Dabigatran Sotagliflozin Inpefa Increased dabigatran exposure and an increased risk of bleeding Details Dabigatran Sotorasib Lumakras Increased dabigatran exposure and an increased risk of bleeding Details Dabigatran Spironolactone Aldactone Increased dabigatran exposure and an increased risk of bleeding Details Dabigatran St John's Wort Reduced dabigatran exposure, reduced efficacy of dabigatran and an increased risk of thrombosis Details Dabigatran Streptokinase An increased risk of bleeding Details Dabigatran Sulfinpyrazone Increased risk of bleeding Details Dabigatran Sulindac Clinoril® An increased risk of bleeding Details Dabigatran Sulodexide An increased risk of bleeding Details Dabigatran Sunitinib Sutent Increased dabigatran etexilate exposure Details Dabigatran Suvorexant Belsomra Increased dabigatran exposure and an increased risk of bleeding Details Dabigatran Tacrolimus Astagraf Increased dabigatran etexilate exposure Details Dabigatran Tazobactam An increased risk of bleeding Details Dabigatran Telaprevir Increased dabigatran exposure and an increased risk of bleeding Details Dabigatran Telithromycin Increased dabigatran exposure and an increased risk of bleeding Details Dabigatran Telmisartan Micardis Increased dabigatran exposure and an increased risk of bleeding Details Dabigatran Tenecteplase An increased risk of bleeding Details Dabigatran Tenoxicam An increased risk of bleeding Details Dabigatran Tepotinib Tepmetko Increased dabigatran exposure and an increased risk of bleeding Details Dabigatran Testosterone Androderm An increased risk of bleeding Details Dabigatran Tiaprofenic Acid An increased risk of bleeding Details Dabigatran Ticagrelor Brilinta Increased dabigatran exposure and an increased risk of bleeding Details Dabigatran Ticlopidine Ticlid® Increased risk of bleeding Details Dabigatran Tinzaparin An increased risk of bleeding Details Dabigatran Tipranavir Aptivus Reduced dabigatran exposure, reduced efficacy of dabigatran and an increased risk of thrombosis Details Dabigatran Tirofiban Increased risk of bleeding Details Dabigatran Tolfenamic Acid An increased risk of bleeding Details Dabigatran Tolmetin Tolectin 600 An increased risk of bleeding Details Dabigatran Tolvaptan Jynarque Increased dabigatran exposure and an increased risk of bleeding Details Dabigatran Trazodone Raldesy Increased risk of bleeding Details Dabigatran Treprostinil Orenitram Increased risk of bleeding Details Dabigatran Tucatinib Tukysa Increased dabigatran exposure and an increased risk of bleeding Details Dabigatran Turmeric An increased risk of bleeding Details Dabigatran Urokinase An increased risk of bleeding Details Dabigatran Valdecoxib Increased risk of bleeding Details Dabigatran Valproic Acid Depakene® Decreased dabigatran exposure and possible subtherapeutic anticoagulation which could lead to a thrombotic event Details Dabigatran Vandetanib Caprelsa Increased dabigatran exposure and an increased risk of bleeding Details Dabigatran Velpatasvir Increased dabigatran exposure and an increased risk of bleeding Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.