Dalteparin and Betrixaban: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Jul 11, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Betrixaban
Dalteparin
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased risk of bleeding
Interaction Deep Dive
Betrixaban increases the risk of bleeding and can cause serious and potentially fatal bleeding. Concurrent use of betrixaban and antiplatelets, other anticoagulants, or thrombolytic agents may increase the risk of bleeding. Avoid concomitant use with other anticoagulants. Promptly evaluate any signs or symptoms of blood loss that occur in a patient treated concomitantly. Discontinue betrixaban in patients with active pathological bleeding1.
Why it happens (mechanism)
Additive effects on hemostasis
Common questions
Can I take Dalteparin and Betrixaban together?
Increased risk of bleeding Always confirm with your pharmacist or prescriber before making any change.
How serious is the Dalteparin and Betrixaban interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Dalteparin or Betrixaban need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: BEVYXXA(R) oral capsules, betrixaban oral capsules. Portola Pharmaceuticals Inc (per FDA), South San Francisco, CA, 2020.
Keep reading about Betrixaban
Keep reading about Dalteparin
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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