Dapsone Topical

Name: Dapsone Topical Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

14 interactions 253 cited references

Also sold as: Aczone Aczone®

About Dapsone Topical

Dapsone topical is used to treat acne in children, teenagers, and adults. Dapsone is in a class of medications called sulfone antibiotics. It works by slowing or stopping the growth of bacteria and to decrease inflammation. Read the full Dapsone Topical drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Articaine Lidocaine Methotrexate Rifabutin Rifampin Warfarin

7 Major 7 Moderate

All (14) Major (7) Moderate (7)

Major

Dapsone Topical Articaine An increased risk of methemoglobinemia Details Dapsone Topical Lidocaine Akten An increased risk of methemoglobinemia Details Dapsone Topical Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Dapsone Topical Rifabutin Mycobutin Reduced dapsone exposure Details Dapsone Topical Rifampin Rifadin Reduced dapsone exposure, reduced efficacy of dapsone, an increased hydroxylamine metabolite of dapsone and an increased the risk... Details Dapsone Topical Warfarin Coumadin Increased International Normalized Ratio (INR) Details Dapsone Topical Zidovudine Retrovir Hematologic toxicity (neutropenia) Details

Moderate

Dapsone Topical Amprenavir An increased risk of dapsone toxicity (hemolytic anemia, methemoglobinemia, lethargy, weakness) Details Dapsone Topical Atazanavir Reyataz An increased risk of hemolytic anemia and symptomatic hyperbilirubinemia Details Dapsone Topical Bacillus Of Calmette And Guerin Vaccine, Live Reduced efficacy of intravesical treatment or vaccination Details Dapsone Topical Fosamprenavir Lexiva An increased risk of dapsone toxicity (hemolytic anemia, methemoglobinemia, lethargy, weakness) Details Dapsone Topical Probenecid An increased risk of dapsone toxicity (hemolytic anemia, methemoglobinemia, lethargy, weakness) Details Dapsone Topical Rifapentine Priftin Decreased dapsone effectiveness Details Dapsone Topical Trimethoprim Primsol An increased risk of dapsone toxicity (hemolytic anemia, methemoglobinemia, peripheral neuropathy) or trimethoprim toxicity (bone... Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.