Deflazacort

228 interactions 335 cited references

Also sold as: Emflaza Emflaza® Jaythari Kymbee Pyquvi

About Deflazacort

Deflazacort is used to treat Duchenne muscular dystrophy (DMD; a progressive disease in which the muscles do not function properly) in adults and children 2 years of age and older. Deflazacort is in a class of medications called corticosteroids. It works by reducing inflammation (swelling) and by changing the way the i… Read the full Deflazacort drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Desmopressin Desmopressin Nasal Ensitrelvir Mifepristone Ofloxacin Otic Aprepitant

4 Contraindicated 172 Major 51 Moderate 1 Minor

All (228) Contraindicated (4) Major (172) Moderate (51) Minor (1)

Major

Deflazacort Pranoprofen Increased risk of gastrointestinal ulcer or bleeding Details Deflazacort Primidone Mysoline Decreased exposure to active metabolite of deflazacort Details Deflazacort Proglumetacin Increased risk of gastrointestinal ulcer or bleeding Details Deflazacort Propyphenazone Increased risk of gastrointestinal ulcer or bleeding Details Deflazacort Proquazone Increased risk of gastrointestinal ulcer or bleeding Details Deflazacort Prulifloxacin An increased risk of tendon rupture Details Deflazacort Rabies Vaccine Imovax An inadequate immunological response to the vaccine, an increased risk of altered immunocompetence and reduced immune response to... Details Deflazacort Relacorilant Lifyorli Reduced relacorilant exposure and reduced efficacy of relacorilant, altered (reduced/increased) glucocorticoids exposure, reduced... Details Deflazacort Ribociclib Kisqali Increased exposure to active metabolite of deflazacort Details Deflazacort Rifampin Rifadin Decreased exposure to active metabolite of deflazacort Details Deflazacort Ritonavir Norvir Increased exposure to active metabolite of deflazacort Details Deflazacort Rofecoxib Increased risk of gastrointestinal ulcer or bleeding Details Deflazacort Rufloxacin An increased risk of tendon rupture Details Deflazacort Salicylic Acid Increased risk of gastrointestinal ulcer or bleeding Details Deflazacort Salsalate Disalcid Increased risk of gastrointestinal ulcer or bleeding Details Deflazacort Saquinavir Increased exposure to active metabolite of deflazacort Details Deflazacort Sargramostim Leukine Increased myeloproliferative effects of sargramostim Details Deflazacort Sodium Salicylate Increased risk of gastrointestinal ulcer or bleeding Details Deflazacort Somatrogon-Ghla Reduced serum cortisol exposure, an increased risk of central (secondary) hypoadrenalism and attenuated growth-promoting effects o... Details Deflazacort Sparfloxacin An increased risk of tendon rupture Details Deflazacort St John's Wort Decreased exposure to active metabolite of deflazacort Details Deflazacort Sulindac Clinoril® Increased risk of gastrointestinal ulcer or bleeding Details Deflazacort Tazemetostat Tazverik Reduced CYP3A substrate exposure and reduced efficacy of CYP3A substrate Details Deflazacort Telaprevir Increased exposure to active metabolite of deflazacort Details Deflazacort Telithromycin Increased exposure to active metabolite of deflazacort Details Deflazacort Tenoxicam Increased risk of gastrointestinal ulcer or bleeding Details Deflazacort Tiaprofenic Acid Increased risk of gastrointestinal ulcer or bleeding Details Deflazacort Tolfenamic Acid Increased risk of gastrointestinal ulcer or bleeding Details Deflazacort Tolmetin Tolectin 600 Increased risk of gastrointestinal ulcer or bleeding Details Deflazacort Tosufloxacin An increased risk of tendon rupture Details Deflazacort Upadacitinib Rinvoq Increased risk of gastrointestinal perforations Details Deflazacort Valdecoxib Increased risk of gastrointestinal ulcer or bleeding Details Deflazacort Verapamil Calan Increased exposure to active metabolite of deflazacort Details Deflazacort Voriconazole Vfend Increased exposure to active metabolite of deflazacort, an increased risk of Cushing’s syndrome and an increased risk of adrenal d... Details Deflazacort Diclofenac Ophthalmic Voltaren® Eye Drops Increased risk of gastrointestinal ulcer or bleeding Details Deflazacort Diclofenac Topical (Actinic Keratosis) Pennsaid Increased risk of gastrointestinal ulcer or bleeding Details Deflazacort Diclofenac Topical (Arthritis Pain) Pennsaid® Increased risk of gastrointestinal ulcer or bleeding Details Deflazacort Diclofenac Transdermal Patch Flector Increased risk of gastrointestinal ulcer or bleeding Details Deflazacort Flurbiprofen Ophthalmic Ocufen Increased risk of gastrointestinal ulcer or bleeding Details Deflazacort Gatifloxacin Ophthalmic Zymar® An increased risk of tendon rupture Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.