Desonide

Name: Desonide Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

33 interactions 156 cited references

Also sold as: Desowen Desrx Lokara Tridesilon Verdeso

Read the full Desonide drug information page

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Mifepristone Desmopressin Nasal Desmopressin Upadacitinib Bupropion Carbamazepine

3 Contraindicated 20 Major 10 Moderate

All (33) Contraindicated (3) Major (20) Moderate (10)

Major

Desonide Aspirin Acuprin® An increased risk of salicylism subsequent to withdrawal of corticosteroids Details Desonide Aspirin Rectal Aspirin An increased risk of salicylism subsequent to withdrawal of corticosteroids Details Desonide Bemiparin Increased risk of bleeding Details Desonide Bupropion Aplenzin Lowering of the seizure threshold Details Desonide Carbamazepine Carbatrol Reduced corticosteroids exposure and reduced efficacy of corticosteroids Details Desonide Cosyntropin False elevations of plasma cortisol levels Details Desonide Ethinyl Estradiol Increased corticosteroid exposure Details Desonide Fosphenytoin Cerebyx Reduced corticosteroid exposure Details Desonide Insulin Aspart, Recombinant Fiasp Reduced blood glucose lowering effect of insulin Details Desonide Insulin Glargine, Recombinant Basaglar Reduced blood glucose lowering effect of insulin Details Desonide Insulin Icodec-Abae Awiqli Reduced efficacy of insulin icodec-abae Details Desonide Lutetium Lu 177 Dotatate Decreased lutetium Lu 177 dotatate efficacy Details Desonide Macimorelin False-positive or false-negative adult growth hormone deficiency diagnosis Details Desonide Nadroparin Increased risk of bleeding Details Desonide Phenytoin Dilantin Reduced corticosteroid exposure Details Desonide Rabies Vaccine Imovax An inadequate immunological response to the vaccine, an increased risk of altered immunocompetence and reduced immune response to... Details Desonide Relacorilant Lifyorli Reduced relacorilant exposure and reduced efficacy of relacorilant, reduced glucocorticoids exposure and reduced efficacy of gluco... Details Desonide Sargramostim Leukine Increased myeloproliferative effects of sargramostim Details Desonide Somatrogon-Ghla Reduced serum cortisol exposure, an increased risk of central (secondary) hypoadrenalism and attenuated growth-promoting effects o... Details Desonide Upadacitinib Rinvoq Increased risk of gastrointestinal perforations Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.