Dexamethasone Ophthalmic and Zuranolone: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Zuranolone
Dexamethasone Ophthalmic
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Reduced zuranolone exposure and reduced efficacy of zuranolone
Interaction Deep Dive
Concomitant use of zuranolone with a CYP3A inducer decreases the exposure of zuranolone, possibly reducing its efficacy. Avoid concomitant use of zuranolone with a CYP3A inducer. In a drug interaction study, coadministration of zuranolone with rifAMPin (a CYP3A inducer) decreased the exposure of zuranolone. The geometric mean ratio of zuranolone with and without rifAMPin for Cmax and AUC were 0.31 and 0.15 respectively1.
Why it happens (mechanism)
Induction of CYP3A-mediated metabolism of zuranolone
Literature reports
1 report — tap to read
a) In a drug interaction study, coadministration of zuranolone with rifAMPin (a CYP3A inducer) decreased the exposure of zuranolone. The geometric mean ratio of zuranolone with and without rifAMPin for Cmax and AUC were 0.31 and 0.15 respectively 1.
Common questions
Can I take Dexamethasone Ophthalmic and Zuranolone together?
Reduced zuranolone exposure and reduced efficacy of zuranolone Always confirm with your pharmacist or prescriber before making any change.
How serious is the Dexamethasone Ophthalmic and Zuranolone interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "probable". Good supporting evidence, though not definitively proven.
Questions for your pharmacist
- Does my dose of Dexamethasone Ophthalmic or Zuranolone need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: ZURZUVAE(TM) oral capsules, zuranolone oral capsules. Biogen Inc (per FDA), Cambridge, MA, 2023. DailyMed
Keep reading about Zuranolone
Keep reading about Dexamethasone Ophthalmic
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Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
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