Zuranolone

26 interactions 2 explained in plain English

Also sold as: Zurzuvae

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Cetirizine Ophthalmic Nevirapine Diphenhydramine Topical Dexamethasone Ophthalmic Butorphanol Injection Butorphanol Nasal Spray

26 Major

All (26) Major (26)

Major

Zuranolone Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of CNS depression Details Zuranolone Buprenorphine Belbuca Explained An increased risk of CNS depression Details Zuranolone Aripiprazole Injection Abilify An increased risk of CNS depression Details Zuranolone Asenapine Transdermal Patch Secuado An increased risk of CNS depression Details Zuranolone Butorphanol Injection Butorphic An increased risk of CNS depression Details Zuranolone Butorphanol Nasal Spray Stadol® NS An increased risk of CNS depression Details Zuranolone Cetirizine Injection Aller-Tec An increased risk of CNS depression Details Zuranolone Cetirizine Ophthalmic Zerviate An increased risk of CNS depression Details Zuranolone Dexamethasone Injection Decadron Reduced zuranolone exposure and reduced efficacy of zuranolone Details Zuranolone Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Reduced zuranolone exposure and reduced efficacy of zuranolone Details Zuranolone Diazepam Nasal Spray Valtoco An increased risk of CNS depression Details Zuranolone Diazepam Rectal Diastat An increased risk of CNS depression Details Zuranolone Diphenhydramine Injection Banophen An increased risk of CNS depression Details Zuranolone Diphenhydramine Topical Afterbite with Antihistamine An increased risk of CNS depression Details Zuranolone Esketamine Nasal Spray Spravato An increased risk of CNS depression Details Zuranolone Fentanyl Transdermal Patch Duragesic® An increased risk of CNS depression Details Zuranolone Hydromorphone Injection Dilaudid An increased risk of CNS depression Details Zuranolone Hydromorphone Rectal available generically An increased risk of CNS depression Details Zuranolone Ketoconazole Topical Extina® Foam Increased zuranolone exposure and an increased risk of zuranolone-related adverse effects Details Zuranolone Letermovir Injection Prevymis Increased CYP3A substrate exposure Details Zuranolone Midazolam Nasal Spray Nayzilam An increased risk of CNS depression Details Zuranolone Midazolam Injection Nayzilam An increased risk of CNS depression Details Zuranolone Morphine Injection Astramorph® PF An increased risk of CNS depression Details Zuranolone Nafcillin Injection Unipen® Injection Reduced zuranolone exposure and reduced efficacy of zuranolone Details Zuranolone Nalbuphine Injection Nubain® An increased risk of CNS depression Details Zuranolone Nevirapine Viramune Reduced zuranolone exposure and reduced efficacy of zuranolone Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.