Dexketoprofen

91 interactions 5 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Dexketoprofen Fondaparinux Injection Arixtra An increased risk of bleeding Details Dexketoprofen Furosemide Injection Disal Reduced diuretic effectiveness and possible nephrotoxicity Details Dexketoprofen Heparin An increased risk of bleeding Details Dexketoprofen Heparin Injection Lipo-Hepin® An increased risk of bleeding Details Dexketoprofen Hydrocortisone Ala-Cort Increased risk of gastrointestinal ulcer or bleeding Details Dexketoprofen Hydrocortisone Injection A-Hydrocort® Increased risk of gastrointestinal ulcer or bleeding Details Dexketoprofen Ibuprofen Addaprin Increased risk of bleeding Details Dexketoprofen Iloprost Aurlumyn An increased risk of bleeding Details Dexketoprofen Ketoprofen Actron® Increased risk of bleeding Details Dexketoprofen Lithium Carbonate Lithobid Increased lithium exposure and an increased risk of lithium toxicity Details Dexketoprofen Meclofenamate Meclodium® Increased risk of bleeding Details Dexketoprofen Mefenamic Acid Ponstel® Increased risk of bleeding Details Dexketoprofen Meloxicam Alloxate Increased risk of bleeding Details Dexketoprofen Meloxicam Injection Alloxate Increased risk of bleeding Details Dexketoprofen Melphalan Alkeran An increased risk of bleeding Details Dexketoprofen Melphalan Injection Alkeran An increased risk of bleeding Details Dexketoprofen Mesalamine Apriso Increased risk of bleeding Details Dexketoprofen Mesalamine Rectal Canasa Increased risk of bleeding Details Dexketoprofen Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Dexketoprofen Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Dexketoprofen Nabumetone Relafen Increased risk of bleeding Details Dexketoprofen Naproxen Aleve Increased risk of bleeding Details Dexketoprofen Pemetrexed Injection Alimta Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details

Moderate

Dexketoprofen Lisinopril Prinivil Explained Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Dexketoprofen Atenolol Tenormin Explained Reduced antihypertensive effect Details Dexketoprofen Acebutolol Sectral® Reduced antihypertensive effect Details Dexketoprofen Benazepril Lotensin Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Dexketoprofen Azilsartan Edarbi Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Dexketoprofen Betaxolol Betoptic S Reduced antihypertensive effect Details Dexketoprofen Betaxolol Ophthalmic Betoptic® Reduced antihypertensive effect Details Dexketoprofen Bisoprolol Zebeta® Reduced antihypertensive effect Details Dexketoprofen Captopril Capoten® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Dexketoprofen Desmopressin Nasal Concentraid® Increased risk of water intoxication with hyponatremia Details Dexketoprofen Enalapril Epaned Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Dexketoprofen Eprosartan Teveten® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Dexketoprofen Esmolol Brevibloc Reduced antihypertensive effect Details Dexketoprofen Fosinopril Monopril® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Dexketoprofen Irbesartan Avapro Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Dexketoprofen Labetalol Normodyne® Reduced antihypertensive effect Details Dexketoprofen Levobunolol Ophthalmic AKBeta® Reduced antihypertensive effect Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.