Diacetylmorphine

20 interactions 2 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Acetaminophen And Codeine Buprenorphine Fentanyl Transdermal Patch Morphine Injection Clopidogrel Diazepam Nasal Spray
18 Major 2 Moderate
All (20) Major (18) Moderate (2)

Major

Diacetylmorphine Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of respiratory and CNS depression Details Diacetylmorphine Buprenorphine Belbuca Explained An increased risk of respiratory depression and CNS depression Details Diacetylmorphine Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Diacetylmorphine Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Diacetylmorphine Clopidogrel Plavix Reduced efficacy of clopidogrel Details Diacetylmorphine Diazepam Nasal Spray Valtoco Increased risk of profound sedation, respiratory and CNS depression, coma and death Details Diacetylmorphine Diazepam Rectal Diastat Increased risk of profound sedation, respiratory and CNS depression, coma and death Details Diacetylmorphine Esketamine Nasal Spray Spravato Increased risk of sedation Details Diacetylmorphine Fentanyl Transdermal Patch Duragesic® Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Diacetylmorphine Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression Details Diacetylmorphine Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression Details Diacetylmorphine Lacosamide Injection Motpoly An increased risk of CNS depression Details Diacetylmorphine Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Diacetylmorphine Metoclopramide Injection Gimoti Increased risk of CNS depression Details Diacetylmorphine Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Diacetylmorphine Midazolam Nasal Spray Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Diacetylmorphine Midazolam Injection Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Diacetylmorphine Morphine Injection Astramorph® PF Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details

Moderate

Diacetylmorphine Clonidine Transdermal Patch Catapres An increased risk of sedation and somnolence Details Diacetylmorphine Desmopressin Nasal Concentraid® Increased risk of water intoxication with hyponatremia Details

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