Diazepam

Name: Diazepam Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

40 interactions 5 explained in plain English

Also sold as: Diastat Libervant Valium Valtoco

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Diphenhydramine Injection Abametapir Omeprazole Buprenorphine Orlistat Fentanyl Transdermal Patch

28 Major 12 Moderate

All (40) Major (28) Moderate (12)

Moderate

Diazepam Amitriptyline Elavil Explained Psychomotor deficits (decreased reaction time, decreased vigilance) Details Diazepam Clonidine Transdermal Patch Catapres An increased risk of sedation and somnolence Details Diazepam Digoxin Cardoxin® Digoxin toxicity (nausea, vomiting, cardiac arrhythmias) Details Diazepam Disulfiram Antabuse An increased risk of central nervous system depression Details Diazepam Esomeprazole Nexium Increased exposure of diazepam Details Diazepam Esomeprazole Injection Nexium Increased exposure of diazepam Details Diazepam Estradiol Delestrogen Diazepam toxicity (CNS depression, hypotension) Details Diazepam Estradiol Topical Divigel Diazepam toxicity (CNS depression, hypotension) Details Diazepam Estradiol Transdermal Patch Alora® Diazepam toxicity (CNS depression, hypotension) Details Diazepam Folic Acid Folacin Reduced folic acid exposure and reduced efficacy of folic acid Details Diazepam Levonorgestrel After banger Diazepam toxicity (CNS depression, hypotension) Details Diazepam Levonorgestrel Intrauterine System Kyleena Diazepam toxicity (CNS depression, hypotension) Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.