Diclofenac Ophthalmic

268 interactions 703 cited references

Also sold as: Voltaren® Eye Drops

About Diclofenac Ophthalmic

Diclofenac ophthalmic solution is used to treat eye pain, redness, and swelling in patients who are recovering from cataract surgery (procedure to treat clouding of the lens in the eye). Diclofenac ophthalmic solution is also used to temporarily relieve eye pain and sensitivity to light in patients who are recovering f… Read the full Diclofenac Ophthalmic drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Xipamide Magnesium Salicylate Lumiracoxib Loxoprofen Lornoxicam

1 Contraindicated 197 Major 70 Moderate

All (268) Contraindicated (1) Major (197) Moderate (70)

Contraindicated

Diclofenac Ophthalmic Ketorolac Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details

Major

Diclofenac Ophthalmic Abciximab An increased risk of bleeding Details Diclofenac Ophthalmic Acenocoumarol An increased risk of bleeding Details Diclofenac Ophthalmic Amiloride Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Diclofenac Ophthalmic Amineptine An increased risk of bleeding Details Diclofenac Ophthalmic Amitriptyline Elavil An increased risk of bleeding Details Diclofenac Ophthalmic Amitriptylinoxide An increased risk of bleeding Details Diclofenac Ophthalmic Amoxapine An increased risk of bleeding Details Diclofenac Ophthalmic Anagrelide Agrylin An increased risk of bleeding Details Diclofenac Ophthalmic Apalutamide Erleada Reduced CYP2C9 substrates exposure Details Diclofenac Ophthalmic Apixaban Eliquis An increased risk of bleeding Details Diclofenac Ophthalmic Ardeparin An increased risk of bleeding Details Diclofenac Ophthalmic Argatroban An increased risk of bleeding Details Diclofenac Ophthalmic Aspirin Acuprin® An increased risk of bleeding, decreased renal function, and an increased risk of gastrointestinal adverse events Details Diclofenac Ophthalmic Azathioprine Azasan An increased risk of hepatotoxicity Details Diclofenac Ophthalmic Bemetizide Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Ophthalmic Bemiparin An increased risk of bleeding Details Diclofenac Ophthalmic Bendroflumethiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Ophthalmic Benzthiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Ophthalmic Betrixaban Bevyxxa® An increased risk of bleeding Details Diclofenac Ophthalmic Bivalirudin Angiomax An increased risk of bleeding Details Diclofenac Ophthalmic Budesonide Entocort Increased risk of gastrointestinal ulcer or bleeding Details Diclofenac Ophthalmic Bumetanide Bumex Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Ophthalmic Cangrelor Kengreal An increased risk of bleeding Details Diclofenac Ophthalmic Capecitabine Xeloda Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Diclofenac Ophthalmic Ceritinib Zykadia Increased exposure of CYP2C9 substrate Details Diclofenac Ophthalmic Certoparin An increased risk of bleeding Details Diclofenac Ophthalmic Chlorothiazide Diuril Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Ophthalmic Chlorthalidone Hemiclor Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Ophthalmic Cilostazol Pletal® An increased risk of bleeding Details Diclofenac Ophthalmic Citalopram Celexa An increased risk of bleeding Details Diclofenac Ophthalmic Clomipramine Anafranil An increased risk of bleeding Details Diclofenac Ophthalmic Clopamide Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Ophthalmic Clopidogrel Plavix An increased risk of bleeding Details Diclofenac Ophthalmic Cyclopenthiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Ophthalmic Cyclosporine Atopica An increased risk of cycloSPORINE nephrotoxicity Details Diclofenac Ophthalmic Cyclothiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Ophthalmic Dabigatran Etexilate An increased risk of bleeding Details Diclofenac Ophthalmic Dalteparin Fragmin An increased risk of bleeding Details Diclofenac Ophthalmic Danaparoid An increased risk of bleeding Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.