Diclofenac Ophthalmic

268 interactions 703 cited references

Also sold as: Voltaren® Eye Drops

About Diclofenac Ophthalmic

Diclofenac ophthalmic solution is used to treat eye pain, redness, and swelling in patients who are recovering from cataract surgery (procedure to treat clouding of the lens in the eye). Diclofenac ophthalmic solution is also used to temporarily relieve eye pain and sensitivity to light in patients who are recovering f… Read the full Diclofenac Ophthalmic drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Xipamide Magnesium Salicylate Lumiracoxib Loxoprofen Lornoxicam

1 Contraindicated 197 Major 70 Moderate

All (268) Contraindicated (1) Major (197) Moderate (70)

Major

Diclofenac Ophthalmic Deferiprone Ferriprox Decreased deferiprone clearance and increased deferiprone plasma concentrations Details Diclofenac Ophthalmic Deflazacort Emflaza Increased risk of gastrointestinal ulcer or bleeding Details Diclofenac Ophthalmic Desipramine Norpramin An increased risk of bleeding Details Diclofenac Ophthalmic Desirudin Iprivask An increased risk of bleeding Details Diclofenac Ophthalmic Desvenlafaxine Pristiq An increased risk of bleeding Details Diclofenac Ophthalmic Deutivacaftor Increased CYP2C9 substrate exposure Details Diclofenac Ophthalmic Dexamethasone Increased risk of gastrointestinal ulcer or bleeding Details Diclofenac Ophthalmic Dexketoprofen Increased risk of bleeding Details Diclofenac Ophthalmic Diazoxide Proglycem Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Ophthalmic Dibenzepin An increased risk of bleeding Details Diclofenac Ophthalmic Diflunisal Dolobid Increased risk of bleeding Details Diclofenac Ophthalmic Dipyridamole Permole® An increased risk of bleeding Details Diclofenac Ophthalmic Dipyrone Increased risk of bleeding Details Diclofenac Ophthalmic Dothiepin An increased risk of bleeding Details Diclofenac Ophthalmic Doxepin Prudoxin An increased risk of bleeding Details Diclofenac Ophthalmic Doxifluridine Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Diclofenac Ophthalmic Droxicam Increased risk of bleeding Details Diclofenac Ophthalmic Duloxetine An increased risk of bleeding Details Diclofenac Ophthalmic Edoxaban Savaysa An increased risk of bleeding Details Diclofenac Ophthalmic Emtricitabine Emtriva Increased emtricitabine exposure and an increased risk of emtricitabine-related adverse effects Details Diclofenac Ophthalmic Enoxaparin Lovenox An increased risk of bleeding Details Diclofenac Ophthalmic Eplerenone Inspra Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Diclofenac Ophthalmic Epoprostenol Flolan An increased risk of bleeding Details Diclofenac Ophthalmic Eptifibatide An increased risk of bleeding Details Diclofenac Ophthalmic Escitalopram Lexapro An increased risk of bleeding Details Diclofenac Ophthalmic Ethacrynic Acid Edecrin Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Ophthalmic Etodolac Lodine Increased risk of bleeding Details Diclofenac Ophthalmic Etofenamate Increased risk of bleeding Details Diclofenac Ophthalmic Etoricoxib Increased risk of bleeding Details Diclofenac Ophthalmic Etozolin Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Ophthalmic Felbinac Increased risk of bleeding Details Diclofenac Ophthalmic Fenoprofen Fenopron Increased risk of bleeding Details Diclofenac Ophthalmic Fepradinol Increased risk of bleeding Details Diclofenac Ophthalmic Feprazone Increased risk of bleeding Details Diclofenac Ophthalmic Feverfew Increased risk of adverse effects from the nonsteroidal antiinflammatory agent (ie, gastrointestinal, renal effects) Details Diclofenac Ophthalmic Floctafenine Increased risk of bleeding Details Diclofenac Ophthalmic Flufenamic Acid Increased risk of bleeding Details Diclofenac Ophthalmic Fluorouracil Adrucil Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Diclofenac Ophthalmic Fluoxetine RECONCILE An increased risk of bleeding Details Diclofenac Ophthalmic Flurbiprofen Ansaid Increased risk of bleeding Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.