Diclofenac Ophthalmic

268 interactions 703 cited references

Also sold as: Voltaren® Eye Drops

About Diclofenac Ophthalmic

Diclofenac ophthalmic solution is used to treat eye pain, redness, and swelling in patients who are recovering from cataract surgery (procedure to treat clouding of the lens in the eye). Diclofenac ophthalmic solution is also used to temporarily relieve eye pain and sensitivity to light in patients who are recovering f… Read the full Diclofenac Ophthalmic drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Xipamide Magnesium Salicylate Lumiracoxib Loxoprofen Lornoxicam

1 Contraindicated 197 Major 70 Moderate

All (268) Contraindicated (1) Major (197) Moderate (70)

Major

Diclofenac Ophthalmic Fluvoxamine An increased risk of bleeding Details Diclofenac Ophthalmic Fondaparinux Arixtra An increased risk of bleeding Details Diclofenac Ophthalmic Furosemide Disal Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Ophthalmic Gossypol Increased risk of adverse gastrointestinal effects Details Diclofenac Ophthalmic Heparin An increased risk of bleeding Details Diclofenac Ophthalmic Hydrochlorothiazide Inzirqo Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Ophthalmic Hydrocortisone Ala-Cort Increased risk of gastrointestinal ulcer or bleeding Details Diclofenac Ophthalmic Hydroflumethiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Ophthalmic Ibuprofen Addaprin Increased risk of bleeding Details Diclofenac Ophthalmic Iloprost Aurlumyn An increased risk of bleeding Details Diclofenac Ophthalmic Imipramine An increased risk of bleeding Details Diclofenac Ophthalmic Indapamide Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Ophthalmic Inotersen Increased risk of bleeding Details Diclofenac Ophthalmic Ketoprofen Actron® Increased risk of bleeding Details Diclofenac Ophthalmic Lepirudin An increased risk of bleeding Details Diclofenac Ophthalmic Levoketoconazole Recorlev Increased risk of serious hepatotoxicity and drug-induced liver injury Details Diclofenac Ophthalmic Levomilnacipran An increased risk of bleeding Details Diclofenac Ophthalmic Lithium Increased lithium exposure and an increased risk of lithium toxicity Details Diclofenac Ophthalmic Lofepramine An increased risk of bleeding Details Diclofenac Ophthalmic Lornoxicam Increased risk of bleeding Details Diclofenac Ophthalmic Loxoprofen Increased risk of bleeding Details Diclofenac Ophthalmic Lumiracoxib Increased risk of bleeding Details Diclofenac Ophthalmic Magnesium Salicylate Increased risk of bleeding Details Diclofenac Ophthalmic Meadowsweet Increased risk of bleeding Details Diclofenac Ophthalmic Meclofenamate Meclodium® Increased risk of bleeding Details Diclofenac Ophthalmic Mefenamic Acid Ponstel® Increased risk of bleeding Details Diclofenac Ophthalmic Melitracen An increased risk of bleeding Details Diclofenac Ophthalmic Meloxicam Alloxate Increased risk of bleeding Details Diclofenac Ophthalmic Melphalan Alkeran An increased risk of bleeding Details Diclofenac Ophthalmic Mercaptopurine Purinethol® An increased risk of hepatotoxicity Details Diclofenac Ophthalmic Mesalamine Apriso Increased risk of bleeding Details Diclofenac Ophthalmic Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Diclofenac Ophthalmic Methyclothiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Ophthalmic Methylprednisolone Depo-Medrol Increased risk of gastrointestinal ulcer or bleeding Details Diclofenac Ophthalmic Metolazone Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Ophthalmic Milnacipran Savella An increased risk of bleeding Details Diclofenac Ophthalmic Morniflumate Increased risk of bleeding Details Diclofenac Ophthalmic Nabumetone Relafen Increased risk of bleeding Details Diclofenac Ophthalmic Nadroparin An increased risk of bleeding Details Diclofenac Ophthalmic Naproxen Aleve Increased risk of bleeding Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.