Diclofenac Ophthalmic

268 interactions 703 cited references

Also sold as: Voltaren® Eye Drops

About Diclofenac Ophthalmic

Diclofenac ophthalmic solution is used to treat eye pain, redness, and swelling in patients who are recovering from cataract surgery (procedure to treat clouding of the lens in the eye). Diclofenac ophthalmic solution is also used to temporarily relieve eye pain and sensitivity to light in patients who are recovering f… Read the full Diclofenac Ophthalmic drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Xipamide Magnesium Salicylate Lumiracoxib Loxoprofen Lornoxicam

1 Contraindicated 197 Major 70 Moderate

All (268) Contraindicated (1) Major (197) Moderate (70)

Major

Diclofenac Ophthalmic Nefazodone An increased risk of bleeding Details Diclofenac Ophthalmic Nepafenac Ilevro Increased risk of bleeding Details Diclofenac Ophthalmic Niflumic Acid Increased risk of bleeding Details Diclofenac Ophthalmic Nimesulide Increased risk of bleeding Details Diclofenac Ophthalmic Nimesulide Beta Cyclodextrin Increased risk of bleeding Details Diclofenac Ophthalmic Nortriptyline An increased risk of bleeding Details Diclofenac Ophthalmic Olsalazine Dipentum Increased risk of bleeding Details Diclofenac Ophthalmic Opipramol An increased risk of bleeding Details Diclofenac Ophthalmic Oxaprozin Coxanto Increased risk of bleeding Details Diclofenac Ophthalmic Oxyphenbutazone Increased risk of bleeding Details Diclofenac Ophthalmic Parecoxib Increased risk of bleeding Details Diclofenac Ophthalmic Parnaparin An increased risk of bleeding Details Diclofenac Ophthalmic Paroxetine Paxil An increased risk of bleeding Details Diclofenac Ophthalmic Pemetrexed Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details Diclofenac Ophthalmic Pentosan Polysulfate Sodium An increased risk of bleeding Details Diclofenac Ophthalmic Pentoxifylline Pentoxil® An increased risk of bleeding Details Diclofenac Ophthalmic Phenindione An increased risk of bleeding Details Diclofenac Ophthalmic Phenprocoumon An increased risk of bleeding Details Diclofenac Ophthalmic Phenylbutazone Equi-Phar Increased risk of bleeding Details Diclofenac Ophthalmic Phenyl Salicylate Increased risk of bleeding Details Diclofenac Ophthalmic Piketoprofen Increased risk of bleeding Details Diclofenac Ophthalmic Piretanide Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Ophthalmic Piroxicam Feldene Increased risk of bleeding Details Diclofenac Ophthalmic Polythiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Ophthalmic Potassium Citrate Urocit-K Increased risk of hyperkalemia Details Diclofenac Ophthalmic Prasugrel Effient An increased risk of bleeding Details Diclofenac Ophthalmic Prednisolone Flo-Pred® Increased risk of gastrointestinal ulcer or bleeding Details Diclofenac Ophthalmic Prednisone Deltasone Increased risk of gastrointestinal ulcer or bleeding Details Diclofenac Ophthalmic Proglumetacin Increased risk of bleeding Details Diclofenac Ophthalmic Propyphenazone Increased risk of bleeding Details Diclofenac Ophthalmic Proquazone Increased risk of bleeding Details Diclofenac Ophthalmic Protein C Ceprotin An increased risk of bleeding Details Diclofenac Ophthalmic Protriptyline An increased risk of bleeding Details Diclofenac Ophthalmic Quinethazone Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Ophthalmic Reviparin An increased risk of bleeding Details Diclofenac Ophthalmic Rivaroxaban Xarelto An increased risk of bleeding Details Diclofenac Ophthalmic Rofecoxib Increased risk of bleeding Details Diclofenac Ophthalmic Salicylamide Increased risk of bleeding Details Diclofenac Ophthalmic Salicylic Acid Increased risk of bleeding Details Diclofenac Ophthalmic Salsalate Disalcid Increased risk of bleeding Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.