Diclofenac Ophthalmic

268 interactions 703 cited references
Also sold as: Voltaren® Eye Drops
About Diclofenac Ophthalmic

Diclofenac ophthalmic solution is used to treat eye pain, redness, and swelling in patients who are recovering from cataract surgery (procedure to treat clouding of the lens in the eye). Diclofenac ophthalmic solution is also used to temporarily relieve eye pain and sensitivity to light in patients who are recovering f… Read the full Diclofenac Ophthalmic drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Xipamide Magnesium Salicylate Lumiracoxib Loxoprofen Lornoxicam
1 Contraindicated 197 Major 70 Moderate
All (268) Contraindicated (1) Major (197) Moderate (70)

Major

Diclofenac Ophthalmic Selexipag Uptravi An increased risk of bleeding Details Diclofenac Ophthalmic Sertraline An increased risk of bleeding Details Diclofenac Ophthalmic Sibutramine An increased risk of bleeding Details Diclofenac Ophthalmic Sodium Salicylate Increased risk of bleeding Details Diclofenac Ophthalmic Sparsentan Filspari An increased risk of kidney injury, reduced CYP2C9 substrate exposure and reduced CYP2C9 substrate efficacy Details Diclofenac Ophthalmic Spironolactone Aldactone Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Diclofenac Ophthalmic Sulfasalazine Azulfidine Increased risk of bleeding Details Diclofenac Ophthalmic Sulfinpyrazone An increased risk of bleeding Details Diclofenac Ophthalmic Sulindac Clinoril® Increased risk of bleeding Details Diclofenac Ophthalmic Sulodexide An increased risk of bleeding Details Diclofenac Ophthalmic Tacrolimus Astagraf Acute renal failure Details Diclofenac Ophthalmic Tegafur Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Diclofenac Ophthalmic Tenofovir Alafenamide Increased tenofovir alafenamide exposure and an increased risk of tenofovir alafenamide-related adverse effects Details Diclofenac Ophthalmic Tenofovir Disoproxil Fumarate Increased risk of acute renal failure Details Diclofenac Ophthalmic Tenoxicam Increased risk of bleeding Details Diclofenac Ophthalmic Tianeptine An increased risk of bleeding Details Diclofenac Ophthalmic Tiaprofenic Acid Increased risk of bleeding Details Diclofenac Ophthalmic Ticagrelor Brilinta An increased risk of bleeding Details Diclofenac Ophthalmic Ticlopidine Ticlid® An increased risk of bleeding Details Diclofenac Ophthalmic Tinzaparin An increased risk of bleeding Details Diclofenac Ophthalmic Tirofiban An increased risk of bleeding Details Diclofenac Ophthalmic Tolfenamic Acid Increased risk of bleeding Details Diclofenac Ophthalmic Tolmetin Tolectin 600 Increased risk of bleeding Details Diclofenac Ophthalmic Torsemide Soaanz Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Ophthalmic Trazodone Raldesy An increased risk of bleeding Details Diclofenac Ophthalmic Treprostinil Orenitram An increased risk of bleeding Details Diclofenac Ophthalmic Triamterene Dyrenium Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Diclofenac Ophthalmic Trichlormethiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Ophthalmic Trimipramine An increased risk of bleeding Details Diclofenac Ophthalmic Trolamine Salicylate Increased risk of bleeding Details Diclofenac Ophthalmic Upadacitinib Rinvoq Increased risk of gastrointestinal perforations Details Diclofenac Ophthalmic Valdecoxib Increased risk of bleeding Details Diclofenac Ophthalmic Venlafaxine An increased risk of bleeding Details Diclofenac Ophthalmic Vilazodone Viibryd An increased risk of bleeding Details Diclofenac Ophthalmic Vorapaxar Zontivity An increased risk of bleeding Details Diclofenac Ophthalmic Vortioxetine Trintellix An increased risk of bleeding Details Diclofenac Ophthalmic Warfarin Coumadin An increased risk of bleeding Details Diclofenac Ophthalmic Xipamide Reduced diuretic effectiveness and possible nephrotoxicity Details

Moderate

Diclofenac Ophthalmic Acebutolol Sectral® Reduced antihypertensive effect Details Diclofenac Ophthalmic Amiodarone Nexterone Increased exposure of diclofenac Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.