Diclofenac Topical (Arthritis Pain)

268 interactions 703 cited references

Also sold as: Pennsaid® Voltaren Voltaren Arthritis Pain®

About Diclofenac Topical (Arthritis Pain)

Nonprescription (over-the-counter) diclofenac topical gel (Voltaren Arthritis Pain) is used to relieve pain from arthritis in certain joints such as those of the knees, ankles, feet, elbows, wrists, and hands. Prescription diclofenac topical solution (Pennsaid) is used to relieve osteoarthritis pain in the knees. Diclo… Read the full Diclofenac Topical (Arthritis Pain) drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Xipamide Hydrocortisone Hydrochlorothiazide Heparin Gossypol

1 Contraindicated 197 Major 70 Moderate

All (268) Contraindicated (1) Major (197) Moderate (70)

Moderate

Diclofenac Topical (Arthritis Pain) Mifepristone Korlym Increased NSAID exposure Details Diclofenac Topical (Arthritis Pain) Moexipril Univasc® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diclofenac Topical (Arthritis Pain) Nadolol Corgard Reduced antihypertensive effect Details Diclofenac Topical (Arthritis Pain) Nebivolol Bystolic Reduced antihypertensive effect Details Diclofenac Topical (Arthritis Pain) Norfloxacin An increased risk of seizures Details Diclofenac Topical (Arthritis Pain) Ofloxacin Floxin® An increased risk of seizures Details Diclofenac Topical (Arthritis Pain) Olmesartan Benicar Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diclofenac Topical (Arthritis Pain) Oxprenolol Reduced antihypertensive effect Details Diclofenac Topical (Arthritis Pain) Penbutolol Levatol® Reduced antihypertensive effect Details Diclofenac Topical (Arthritis Pain) Perindopril Aceon Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diclofenac Topical (Arthritis Pain) Phenobarbital Fidoquel Decreased exposure of diclofenac Details Diclofenac Topical (Arthritis Pain) Pindolol Visken® Reduced antihypertensive effect Details Diclofenac Topical (Arthritis Pain) Pralatrexate Increased pralatrexate exposure Details Diclofenac Topical (Arthritis Pain) Propranolol Hemangeol Reduced antihypertensive effect Details Diclofenac Topical (Arthritis Pain) Quinapril Accupril Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diclofenac Topical (Arthritis Pain) Ramipril Altace Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diclofenac Topical (Arthritis Pain) Rifampin Rifadin Decreased exposure of diclofenac Details Diclofenac Topical (Arthritis Pain) Rifapentine Priftin Decreased exposure of diclofenac Details Diclofenac Topical (Arthritis Pain) Secobarbital Decreased exposure of diclofenac Details Diclofenac Topical (Arthritis Pain) Sotalol Betapace Reduced antihypertensive effect Details Diclofenac Topical (Arthritis Pain) Spirapril Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diclofenac Topical (Arthritis Pain) St John's Wort Decreased exposure of diclofenac Details Diclofenac Topical (Arthritis Pain) Sulfaphenazole Increased exposure of diclofenac Details Diclofenac Topical (Arthritis Pain) Telmisartan Micardis Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diclofenac Topical (Arthritis Pain) Timolol Betimol Reduced antihypertensive effect Details Diclofenac Topical (Arthritis Pain) Trandolapril Mavik® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diclofenac Topical (Arthritis Pain) Valsartan Diovan Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diclofenac Topical (Arthritis Pain) Voriconazole Vfend Increased exposure of diclofenac Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.