Diclofenac Topical (Arthritis Pain)

268 interactions 703 cited references

Also sold as: Pennsaid® Voltaren Voltaren Arthritis Pain®

About Diclofenac Topical (Arthritis Pain)

Nonprescription (over-the-counter) diclofenac topical gel (Voltaren Arthritis Pain) is used to relieve pain from arthritis in certain joints such as those of the knees, ankles, feet, elbows, wrists, and hands. Prescription diclofenac topical solution (Pennsaid) is used to relieve osteoarthritis pain in the knees. Diclo… Read the full Diclofenac Topical (Arthritis Pain) drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

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1 Contraindicated 197 Major 70 Moderate

All (268) Contraindicated (1) Major (197) Moderate (70)

Moderate

Diclofenac Topical (Arthritis Pain) Acebutolol Sectral® Reduced antihypertensive effect Details Diclofenac Topical (Arthritis Pain) Amiodarone Nexterone Increased exposure of diclofenac Details Diclofenac Topical (Arthritis Pain) Aprepitant Aponvie Decreased exposure of diclofenac Details Diclofenac Topical (Arthritis Pain) Atenolol Tenormin Reduced antihypertensive effect Details Diclofenac Topical (Arthritis Pain) Azilsartan Edarbi Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diclofenac Topical (Arthritis Pain) Azilsartan Medoxomil Edarbi Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diclofenac Topical (Arthritis Pain) Benazepril Lotensin Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diclofenac Topical (Arthritis Pain) Betaxolol Betoptic S Reduced antihypertensive effect Details Diclofenac Topical (Arthritis Pain) Bisoprolol Zebeta® Reduced antihypertensive effect Details Diclofenac Topical (Arthritis Pain) Bosentan Decreased exposure of diclofenac Details Diclofenac Topical (Arthritis Pain) Candesartan Atacand Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diclofenac Topical (Arthritis Pain) Captopril Capoten® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diclofenac Topical (Arthritis Pain) Carbamazepine Carbatrol Decreased exposure of diclofenac Details Diclofenac Topical (Arthritis Pain) Carteolol Reduced antihypertensive effect Details Diclofenac Topical (Arthritis Pain) Carvedilol Coreg Reduced antihypertensive effect Details Diclofenac Topical (Arthritis Pain) Celiprolol Reduced antihypertensive effect Details Diclofenac Topical (Arthritis Pain) Cholestyramine Prevalite Decreased diclofenac bioavailability Details Diclofenac Topical (Arthritis Pain) Ciprofloxacin An increased risk of convulsions Details Diclofenac Topical (Arthritis Pain) Colestipol Colestid Decreased diclofenac bioavailability Details Diclofenac Topical (Arthritis Pain) Desmopressin DDAVP Increased risk of water intoxication with hyponatremia Details Diclofenac Topical (Arthritis Pain) Enalapril Epaned Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diclofenac Topical (Arthritis Pain) Enalaprilat Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diclofenac Topical (Arthritis Pain) Entacapone Comtan Increased diclofenac exposure Details Diclofenac Topical (Arthritis Pain) Enzalutamide Xtandi Decreased exposure of diclofenac Details Diclofenac Topical (Arthritis Pain) Eprosartan Teveten® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diclofenac Topical (Arthritis Pain) Esmolol Brevibloc Reduced antihypertensive effect Details Diclofenac Topical (Arthritis Pain) Fluconazole Diflucan Increased exposure of diclofenac Details Diclofenac Topical (Arthritis Pain) Fosaprepitant Emend Injection Decreased exposure of diclofenac Details Diclofenac Topical (Arthritis Pain) Fosinopril Monopril® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diclofenac Topical (Arthritis Pain) Ginkgo An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Irbesartan Avapro Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diclofenac Topical (Arthritis Pain) Labetalol Normodyne® Reduced antihypertensive effect Details Diclofenac Topical (Arthritis Pain) Levobunolol Betagan Reduced antihypertensive effect Details Diclofenac Topical (Arthritis Pain) Levofloxacin Levaquin An increased risk of seizures Details Diclofenac Topical (Arthritis Pain) Lisinopril Prinivil Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diclofenac Topical (Arthritis Pain) L-Methylfolate Decreased l-methylfolate efficacy Details Diclofenac Topical (Arthritis Pain) Losartan Arbli Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diclofenac Topical (Arthritis Pain) Ma Huang Increased risk of developing gastric mucosal lesions Details Diclofenac Topical (Arthritis Pain) Mavacamten Camzyos Reduced CYP2C9 substrate exposure and reduced efficacy of CYP2C9 substrate Details Diclofenac Topical (Arthritis Pain) Metipranolol Reduced antihypertensive effect Details

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