Diclofenac Topical (Arthritis Pain)

268 interactions 703 cited references

Also sold as: Pennsaid® Voltaren Voltaren Arthritis Pain®

About Diclofenac Topical (Arthritis Pain)

Nonprescription (over-the-counter) diclofenac topical gel (Voltaren Arthritis Pain) is used to relieve pain from arthritis in certain joints such as those of the knees, ankles, feet, elbows, wrists, and hands. Prescription diclofenac topical solution (Pennsaid) is used to relieve osteoarthritis pain in the knees. Diclo… Read the full Diclofenac Topical (Arthritis Pain) drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Xipamide Hydrocortisone Hydrochlorothiazide Heparin Gossypol

1 Contraindicated 197 Major 70 Moderate

All (268) Contraindicated (1) Major (197) Moderate (70)

Contraindicated

Diclofenac Topical (Arthritis Pain) Ketorolac Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details

Major

Diclofenac Topical (Arthritis Pain) Abciximab An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Acenocoumarol An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Amiloride Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Diclofenac Topical (Arthritis Pain) Amineptine An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Amitriptyline Elavil An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Amitriptylinoxide An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Amoxapine An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Anagrelide Agrylin An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Apalutamide Erleada Reduced CYP2C9 substrates exposure Details Diclofenac Topical (Arthritis Pain) Apixaban Eliquis An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Ardeparin An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Argatroban An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Aspirin Acuprin® An increased risk of bleeding, decreased renal function, and an increased risk of gastrointestinal adverse events Details Diclofenac Topical (Arthritis Pain) Azathioprine Azasan An increased risk of hepatotoxicity Details Diclofenac Topical (Arthritis Pain) Bemetizide Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Topical (Arthritis Pain) Bemiparin An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Bendroflumethiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Topical (Arthritis Pain) Benzthiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Topical (Arthritis Pain) Betrixaban Bevyxxa® An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Bivalirudin Angiomax An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Budesonide Entocort Increased risk of gastrointestinal ulcer or bleeding Details Diclofenac Topical (Arthritis Pain) Bumetanide Bumex Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Topical (Arthritis Pain) Cangrelor Kengreal An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Capecitabine Xeloda Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Diclofenac Topical (Arthritis Pain) Ceritinib Zykadia Increased exposure of CYP2C9 substrate Details Diclofenac Topical (Arthritis Pain) Certoparin An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Chlorothiazide Diuril Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Topical (Arthritis Pain) Chlorthalidone Hemiclor Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Topical (Arthritis Pain) Cilostazol Pletal® An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Citalopram Celexa An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Clomipramine Anafranil An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Clopamide Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Topical (Arthritis Pain) Clopidogrel Plavix An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Cyclopenthiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Topical (Arthritis Pain) Cyclosporine Atopica An increased risk of cycloSPORINE nephrotoxicity Details Diclofenac Topical (Arthritis Pain) Cyclothiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Topical (Arthritis Pain) Dabigatran Etexilate An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Dalteparin Fragmin An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Danaparoid An increased risk of bleeding Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.