Diclofenac Topical (Arthritis Pain)

268 interactions 703 cited references

Also sold as: Pennsaid® Voltaren Voltaren Arthritis Pain®

About Diclofenac Topical (Arthritis Pain)

Nonprescription (over-the-counter) diclofenac topical gel (Voltaren Arthritis Pain) is used to relieve pain from arthritis in certain joints such as those of the knees, ankles, feet, elbows, wrists, and hands. Prescription diclofenac topical solution (Pennsaid) is used to relieve osteoarthritis pain in the knees. Diclo… Read the full Diclofenac Topical (Arthritis Pain) drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Xipamide Hydrocortisone Hydrochlorothiazide Heparin Gossypol

1 Contraindicated 197 Major 70 Moderate

All (268) Contraindicated (1) Major (197) Moderate (70)

Major

Diclofenac Topical (Arthritis Pain) Deferiprone Ferriprox Decreased deferiprone clearance and increased deferiprone plasma concentrations Details Diclofenac Topical (Arthritis Pain) Deflazacort Emflaza Increased risk of gastrointestinal ulcer or bleeding Details Diclofenac Topical (Arthritis Pain) Desipramine Norpramin An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Desirudin Iprivask An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Desvenlafaxine Pristiq An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Deutivacaftor Increased CYP2C9 substrate exposure Details Diclofenac Topical (Arthritis Pain) Dexamethasone Increased risk of gastrointestinal ulcer or bleeding Details Diclofenac Topical (Arthritis Pain) Dexketoprofen Increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Diazoxide Proglycem Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Topical (Arthritis Pain) Dibenzepin An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Diflunisal Dolobid Increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Dipyridamole Permole® An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Dipyrone Increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Dothiepin An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Doxepin Prudoxin An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Doxifluridine Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Diclofenac Topical (Arthritis Pain) Droxicam Increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Duloxetine An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Edoxaban Savaysa An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Emtricitabine Emtriva Increased emtricitabine exposure and an increased risk of emtricitabine-related adverse effects Details Diclofenac Topical (Arthritis Pain) Enoxaparin Lovenox An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Eplerenone Inspra Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Diclofenac Topical (Arthritis Pain) Epoprostenol Flolan An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Eptifibatide An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Escitalopram Lexapro An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Ethacrynic Acid Edecrin Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Topical (Arthritis Pain) Etodolac Lodine Increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Etofenamate Increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Etoricoxib Increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Etozolin Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Topical (Arthritis Pain) Felbinac Increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Fenoprofen Fenopron Increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Fepradinol Increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Feprazone Increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Feverfew Increased risk of adverse effects from the nonsteroidal antiinflammatory agent (ie, gastrointestinal, renal effects) Details Diclofenac Topical (Arthritis Pain) Floctafenine Increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Flufenamic Acid Increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Fluorouracil Adrucil Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Diclofenac Topical (Arthritis Pain) Fluoxetine RECONCILE An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Flurbiprofen Ansaid Increased risk of bleeding Details

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