Diclofenac Topical (Arthritis Pain)

268 interactions 703 cited references

Also sold as: Pennsaid® Voltaren Voltaren Arthritis Pain®

About Diclofenac Topical (Arthritis Pain)

Nonprescription (over-the-counter) diclofenac topical gel (Voltaren Arthritis Pain) is used to relieve pain from arthritis in certain joints such as those of the knees, ankles, feet, elbows, wrists, and hands. Prescription diclofenac topical solution (Pennsaid) is used to relieve osteoarthritis pain in the knees. Diclo… Read the full Diclofenac Topical (Arthritis Pain) drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Xipamide Hydrocortisone Hydrochlorothiazide Heparin Gossypol

1 Contraindicated 197 Major 70 Moderate

All (268) Contraindicated (1) Major (197) Moderate (70)

Major

Diclofenac Topical (Arthritis Pain) Fluvoxamine An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Fondaparinux Arixtra An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Furosemide Disal Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Topical (Arthritis Pain) Gossypol Increased risk of adverse gastrointestinal effects Details Diclofenac Topical (Arthritis Pain) Heparin An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Hydrochlorothiazide Inzirqo Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Topical (Arthritis Pain) Hydrocortisone Ala-Cort Increased risk of gastrointestinal ulcer or bleeding Details Diclofenac Topical (Arthritis Pain) Hydroflumethiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Topical (Arthritis Pain) Ibuprofen Addaprin Increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Iloprost Aurlumyn An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Imipramine An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Indapamide Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Topical (Arthritis Pain) Inotersen Increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Ketoprofen Actron® Increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Lepirudin An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Levoketoconazole Recorlev Increased risk of serious hepatotoxicity and drug-induced liver injury Details Diclofenac Topical (Arthritis Pain) Levomilnacipran An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Lithium Increased lithium exposure and an increased risk of lithium toxicity Details Diclofenac Topical (Arthritis Pain) Lofepramine An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Lornoxicam Increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Loxoprofen Increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Lumiracoxib Increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Magnesium Salicylate Increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Meadowsweet Increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Meclofenamate Meclodium® Increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Mefenamic Acid Ponstel® Increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Melitracen An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Meloxicam Alloxate Increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Melphalan Alkeran An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Mercaptopurine Purinethol® An increased risk of hepatotoxicity Details Diclofenac Topical (Arthritis Pain) Mesalamine Apriso Increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Diclofenac Topical (Arthritis Pain) Methyclothiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Topical (Arthritis Pain) Methylprednisolone Depo-Medrol Increased risk of gastrointestinal ulcer or bleeding Details Diclofenac Topical (Arthritis Pain) Metolazone Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Topical (Arthritis Pain) Milnacipran Savella An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Morniflumate Increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Nabumetone Relafen Increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Nadroparin An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Naproxen Aleve Increased risk of bleeding Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.