Diclofenac Topical (Arthritis Pain)

268 interactions 703 cited references

Also sold as: Pennsaid® Voltaren Voltaren Arthritis Pain®

About Diclofenac Topical (Arthritis Pain)

Nonprescription (over-the-counter) diclofenac topical gel (Voltaren Arthritis Pain) is used to relieve pain from arthritis in certain joints such as those of the knees, ankles, feet, elbows, wrists, and hands. Prescription diclofenac topical solution (Pennsaid) is used to relieve osteoarthritis pain in the knees. Diclo… Read the full Diclofenac Topical (Arthritis Pain) drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Xipamide Hydrocortisone Hydrochlorothiazide Heparin Gossypol

1 Contraindicated 197 Major 70 Moderate

All (268) Contraindicated (1) Major (197) Moderate (70)

Major

Diclofenac Topical (Arthritis Pain) Nefazodone An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Nepafenac Ilevro Increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Niflumic Acid Increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Nimesulide Increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Nimesulide Beta Cyclodextrin Increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Nortriptyline An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Olsalazine Dipentum Increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Opipramol An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Oxaprozin Coxanto Increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Oxyphenbutazone Increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Parecoxib Increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Parnaparin An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Paroxetine Paxil An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Pemetrexed Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details Diclofenac Topical (Arthritis Pain) Pentosan Polysulfate Sodium An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Pentoxifylline Pentoxil® An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Phenindione An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Phenprocoumon An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Phenylbutazone Equi-Phar Increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Phenyl Salicylate Increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Piketoprofen Increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Piretanide Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Topical (Arthritis Pain) Piroxicam Feldene Increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Polythiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Topical (Arthritis Pain) Potassium Citrate Urocit-K Increased risk of hyperkalemia Details Diclofenac Topical (Arthritis Pain) Prasugrel Effient An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Prednisolone Flo-Pred® Increased risk of gastrointestinal ulcer or bleeding Details Diclofenac Topical (Arthritis Pain) Prednisone Deltasone Increased risk of gastrointestinal ulcer or bleeding Details Diclofenac Topical (Arthritis Pain) Proglumetacin Increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Propyphenazone Increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Proquazone Increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Protein C Ceprotin An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Protriptyline An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Quinethazone Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Topical (Arthritis Pain) Reviparin An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Rivaroxaban Xarelto An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Rofecoxib Increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Salicylamide Increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Salicylic Acid Increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Salsalate Disalcid Increased risk of bleeding Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.