Diclofenac Topical (Arthritis Pain)

268 interactions 703 cited references

Also sold as: Pennsaid® Voltaren Voltaren Arthritis Pain®

About Diclofenac Topical (Arthritis Pain)

Nonprescription (over-the-counter) diclofenac topical gel (Voltaren Arthritis Pain) is used to relieve pain from arthritis in certain joints such as those of the knees, ankles, feet, elbows, wrists, and hands. Prescription diclofenac topical solution (Pennsaid) is used to relieve osteoarthritis pain in the knees. Diclo… Read the full Diclofenac Topical (Arthritis Pain) drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Xipamide Hydrocortisone Hydrochlorothiazide Heparin Gossypol

1 Contraindicated 197 Major 70 Moderate

All (268) Contraindicated (1) Major (197) Moderate (70)

Major

Diclofenac Topical (Arthritis Pain) Selexipag Uptravi An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Sertraline An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Sibutramine An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Sodium Salicylate Increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Sparsentan Filspari An increased risk of kidney injury, reduced CYP2C9 substrate exposure and reduced CYP2C9 substrate efficacy Details Diclofenac Topical (Arthritis Pain) Spironolactone Aldactone Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Diclofenac Topical (Arthritis Pain) Sulfasalazine Azulfidine Increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Sulfinpyrazone An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Sulindac Clinoril® Increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Sulodexide An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Tacrolimus Astagraf Acute renal failure Details Diclofenac Topical (Arthritis Pain) Tegafur Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Diclofenac Topical (Arthritis Pain) Tenofovir Alafenamide Increased tenofovir alafenamide exposure and an increased risk of tenofovir alafenamide-related adverse effects Details Diclofenac Topical (Arthritis Pain) Tenofovir Disoproxil Fumarate Increased risk of acute renal failure Details Diclofenac Topical (Arthritis Pain) Tenoxicam Increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Tianeptine An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Tiaprofenic Acid Increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Ticagrelor Brilinta An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Ticlopidine Ticlid® An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Tinzaparin An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Tirofiban An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Tolfenamic Acid Increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Tolmetin Tolectin 600 Increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Torsemide Soaanz Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Topical (Arthritis Pain) Trazodone Raldesy An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Treprostinil Orenitram An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Triamterene Dyrenium Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Diclofenac Topical (Arthritis Pain) Trichlormethiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Topical (Arthritis Pain) Trimipramine An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Trolamine Salicylate Increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Upadacitinib Rinvoq Increased risk of gastrointestinal perforations Details Diclofenac Topical (Arthritis Pain) Valdecoxib Increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Venlafaxine An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Vilazodone Viibryd An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Vorapaxar Zontivity An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Vortioxetine Trintellix An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Warfarin Coumadin An increased risk of bleeding Details Diclofenac Topical (Arthritis Pain) Xipamide Reduced diuretic effectiveness and possible nephrotoxicity Details

Moderate

Diclofenac Topical (Arthritis Pain) Acebutolol Sectral® Reduced antihypertensive effect Details Diclofenac Topical (Arthritis Pain) Amiodarone Nexterone Increased exposure of diclofenac Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.