Difluprednate Ophthalmic

29 interactions 79 cited references
Also sold as: Durezol Durezol®
About Difluprednate Ophthalmic

Difluprednate ophthalmic is used to treat eye swelling and pain after eye surgery. Difluprednate ophthalmic is in a class of medications called corticosteroids. It works by stopping the release of certain natural substances that cause swelling and pain. Read the full Difluprednate Ophthalmic drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Desmopressin Mifepristone Aspirin Bemiparin Carbamazepine Cosyntropin
2 Contraindicated 18 Major 9 Moderate
All (29) Contraindicated (2) Major (18) Moderate (9)

Contraindicated

Difluprednate Ophthalmic Desmopressin DDAVP Increased risk of severe hyponatremia Details Difluprednate Ophthalmic Mifepristone Korlym An increased risk of autoimmune disorders and an increased risk of acute adrenal insufficiency, that may lead to exacerbation or d... Details

Major

Difluprednate Ophthalmic Aspirin Acuprin® An increased risk of salicylism subsequent to withdrawal of corticosteroids Details Difluprednate Ophthalmic Bemiparin Increased risk of bleeding Details Difluprednate Ophthalmic Carbamazepine Carbatrol Reduced corticosteroids exposure and reduced efficacy of corticosteroids Details Difluprednate Ophthalmic Cosyntropin False elevations of plasma cortisol levels Details Difluprednate Ophthalmic Ethinyl Estradiol Increased corticosteroid exposure Details Difluprednate Ophthalmic Fosphenytoin Cerebyx Reduced corticosteroid exposure Details Difluprednate Ophthalmic Insulin Aspart, Recombinant Fiasp Reduced blood glucose lowering effect of insulin Details Difluprednate Ophthalmic Insulin Glargine, Recombinant Basaglar Reduced blood glucose lowering effect of insulin Details Difluprednate Ophthalmic Insulin Icodec-Abae Awiqli Reduced efficacy of insulin icodec-abae Details Difluprednate Ophthalmic Lutetium Lu 177 Dotatate Decreased lutetium Lu 177 dotatate efficacy Details Difluprednate Ophthalmic Macimorelin False-positive or false-negative adult growth hormone deficiency diagnosis Details Difluprednate Ophthalmic Nadroparin Increased risk of bleeding Details Difluprednate Ophthalmic Phenytoin Dilantin Reduced corticosteroid exposure Details Difluprednate Ophthalmic Rabies Vaccine Imovax An inadequate immunological response to the vaccine, an increased risk of altered immunocompetence and reduced immune response to... Details Difluprednate Ophthalmic Relacorilant Lifyorli Reduced relacorilant exposure and reduced efficacy of relacorilant, reduced glucocorticoids exposure and reduced efficacy of gluco... Details Difluprednate Ophthalmic Sargramostim Leukine Increased myeloproliferative effects of sargramostim Details Difluprednate Ophthalmic Somatrogon-Ghla Reduced serum cortisol exposure, an increased risk of central (secondary) hypoadrenalism and attenuated growth-promoting effects o... Details Difluprednate Ophthalmic Upadacitinib Rinvoq Increased risk of gastrointestinal perforations Details

Moderate

Difluprednate Ophthalmic Auranofin Ridaura Increased risk of auranofin-related adverse effects Details Difluprednate Ophthalmic Gallium Ga 68 Dotatate Increased risk of false negative imaging Details Difluprednate Ophthalmic Indapamide An increased risk of hypokalemia Details Difluprednate Ophthalmic Insulin Afrezza Reduced blood glucose lowering effect of insulin Details Difluprednate Ophthalmic Insulin Lispro, Recombinant Admelog May decrease blood glucose lowering effect of insulin lispro Details Difluprednate Ophthalmic Metformin Fortamet® An increased risk of hyperglycemia and potential loss of glycemic control Details Difluprednate Ophthalmic Olodaterol Striverdi An increased risk of hypokalemia Details Difluprednate Ophthalmic Rotavirus Vaccine, Live An inadequate immunological response to the vaccine Details Difluprednate Ophthalmic Testosterone Androderm Increased risk of edema Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.