Difluprednate Ophthalmic

Name: Difluprednate Ophthalmic Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

29 interactions 79 cited references

Also sold as: Durezol Durezol®

About Difluprednate Ophthalmic

Difluprednate ophthalmic is used to treat eye swelling and pain after eye surgery. Difluprednate ophthalmic is in a class of medications called corticosteroids. It works by stopping the release of certain natural substances that cause swelling and pain. Read the full Difluprednate Ophthalmic drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Desmopressin Mifepristone Aspirin Bemiparin Carbamazepine Cosyntropin

2 Contraindicated 18 Major 9 Moderate

All (29) Contraindicated (2) Major (18) Moderate (9)

Contraindicated

Difluprednate Ophthalmic Desmopressin DDAVP Increased risk of severe hyponatremia Details Difluprednate Ophthalmic Mifepristone Korlym An increased risk of autoimmune disorders and an increased risk of acute adrenal insufficiency, that may lead to exacerbation or d... Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.