Digoxin

453 interactions 2 explained in plain English 980 cited references
Also sold as: Cardoxin® Digitek Digitek® Digox Lanoxicaps® Lanoxin Lanoxin®
About Digoxin

Digoxin is a cardiac glycoside used to treat heart failure and abnormal heart rhythms by strengthening the heart's contractions and slowing heart rate. Read the full Digoxin drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Moderate

Digoxin Ethacrynic Acid Edecrin Increased risk of digoxin toxicity (nausea, vomiting, cardiac arrhythmias) Details Digoxin Etravirine Intelence Increased exposure and plasma concentrations of digoxin Details Digoxin Fenoterol Increased risk of arrhythmias Details Digoxin Flecainide Tambocor® Digoxin toxicity (nausea, vomiting, cardiac arrhythmias) Details Digoxin Frangula Hypokalemia leading to digoxin toxicity Details Digoxin Furosemide Disal Increased risk of digoxin toxicity (nausea, vomiting, cardiac arrhythmias) Details Digoxin Gatifloxacin Zymaxid An increased risk of digoxin toxicity (nausea, vomiting, arrhythmias) Details Digoxin Glecaprevir Increased digoxin exposure Details Digoxin Glycopyrrolate Cuvposa Increased plasma concentrations of digoxin Details Digoxin Indecainide Digoxin toxicity (nausea, vomiting, arrhythmias) Details Digoxin Khella Reduced effectiveness of digoxin Details Digoxin Labetalol Normodyne® Increased risk of bradycardia and possible digitalis glycoside toxicity Details Digoxin Landiolol Increased risk of bradycardia and possible digitalis glycoside toxicity Details Digoxin Lenalidomide Revlimid Increased digoxin plasma concentrations Details Digoxin Levacetylleucine Aqneursa Increased P-gp inhibitor exposure and an increased risk of P-gp substrate-related adverse reactions Details Digoxin Levalbuterol Xopenex Decreased digoxin serum concentrations Details Digoxin Levobunolol Betagan Increased risk of bradycardia and possible digitalis glycoside toxicity Details Digoxin Licorice Increased risk of digoxin toxicity Details Digoxin Lomitapide Increased P-gp substrate exposure Details Digoxin Mepenzolate Increased digoxin exposure Details Digoxin Mepindolol Increased risk of bradycardia and possible digitalis glycoside toxicity Details Digoxin Metipranolol Increased risk of bradycardia and possible digitalis glycoside toxicity Details Digoxin Metoprolol Kapspargo Increased risk of bradycardia and possible digitalis glycoside toxicity Details Digoxin Midodrine Orvaten® Enhanced or precipitated bradycardia, AV block, or arrhythmia Details Digoxin Mitapivat Aqvesme Increased digoxin exposure Details Digoxin Nadolol Corgard Increased risk of bradycardia and possible digitalis glycoside toxicity Details Digoxin Nebivolol Bystolic Increased risk of bradycardia and possible digitalis glycoside toxicity Details Digoxin Oxprenolol Increased risk of bradycardia and possible digitalis glycoside toxicity Details Digoxin Pancuronium An increased risk of cardiac arrhythmias Details Digoxin Penbutolol Levatol® Increased risk of bradycardia and possible digitalis glycoside toxicity Details Digoxin Pibrentasvir Increased digoxin exposure and increased risk of digoxin toxicity Details Digoxin Pindolol Visken® Increased risk of bradycardia and possible digitalis glycoside toxicity Details Digoxin Practolol Increased risk of bradycardia and possible digitalis glycoside toxicity Details Digoxin Propranolol Hemangeol Increased risk of bradycardia and possible digitalis glycoside toxicity Details Digoxin Quinupristin Increased digoxin levels and digoxin toxicity (nausea, vomiting, arrhythmias) Details Digoxin Rifapentine Priftin Decreased cardiac glycoside effectiveness Details Digoxin Rilzabrutinib Wayrilz Increased digoxin exposure and an increased risk of digoxin-related adverse reactions Details Digoxin Roxithromycin Possible digoxin toxicity (nausea, vomiting, arrhythmias) Details Digoxin Senna Black Draught® Increased risk of digoxin toxicity Details Digoxin Sevabertinib Hyrnuo Increased digoxin exposure and an increased risk of digoxin-related adverse reactions Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.