Digoxin

Name: Digoxin Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

453 interactions 2 explained in plain English 980 cited references

Also sold as: Cardoxin® Digitek Digitek® Digox Lanoxicaps® Lanoxin Lanoxin®

About Digoxin

Digoxin is a cardiac glycoside used to treat heart failure and abnormal heart rhythms by strengthening the heart's contractions and slowing heart rate. Read the full Digoxin drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Levoketoconazole Maribavir Cyclosporine Ophthalmic Parathyroid Hormone Injection Mavorixafor Mefenamic Acid

1 Contraindicated 359 Major 91 Moderate 2 Minor

All (453) Contraindicated (1) Major (359) Moderate (91) Minor (2)

Moderate

Digoxin Sparsentan Filspari Increased P-gp substrate exposure and an increased risk of P-gp substrate-related adverse effects Details Digoxin Talinolol Increased risk of bradycardia and possible digitalis glycoside toxicity Details Digoxin Tertatolol Increased risk of bradycardia and possible digitalis glycoside toxicity Details Digoxin Timolol Betimol Increased risk of bradycardia and possible digitalis glycoside toxicity Details Digoxin Torsemide Soaanz Increased risk of digoxin toxicity (nausea, vomiting, cardiac arrhythmias) Details Digoxin Vincristine Marqibo Decreased digoxin effectiveness Details Digoxin Vincristine Sulfate Liposome Marqibo Decreased digoxin effectiveness Details Digoxin Xanomeline Increased oral P-gp substrate with NTI exposure and an increased risk on severity and frequency of oral P-gp substrate with NTI-re... Details Digoxin Furosemide Injection Disal Increased risk of digoxin toxicity (nausea, vomiting, cardiac arrhythmias) Details Digoxin Gatifloxacin Ophthalmic Zymar® An increased risk of digoxin toxicity (nausea, vomiting, arrhythmias) Details Digoxin Levobunolol Ophthalmic AKBeta® Increased risk of bradycardia and possible digitalis glycoside toxicity Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.