Dihydroergotamine Nasal Spray

157 interactions 472 cited references

Also sold as: Migranal Migranal® Nasal Spray Trudhesa Trudhesa® Nasal Spray

About Dihydroergotamine Nasal Spray

Dihydroergotamine is used to treat migraine headaches (severe, throbbing headaches that sometimes are accompanied by nausea and sensitivity to sound and light). Dihydroergotamine is in a class of medications called ergot alkaloids. It works by tightening blood vessels in the brain and by stopping the release of natural… Read the full Dihydroergotamine Nasal Spray drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Troleandomycin Adagrasib Tucatinib Almotriptan Zolmitriptan Vasopressin

62 Contraindicated 79 Major 16 Moderate

All (157) Contraindicated (62) Major (79) Moderate (16)

Contraindicated

Dihydroergotamine Nasal Spray Nirmatrelvir Increased risk of ergot toxicity Details Dihydroergotamine Nasal Spray Norepinephrine Increased risk of elevation of blood pressure Details Dihydroergotamine Nasal Spray Paritaprevir Increased dihydroergotamine exposure and an increased risk of dihydroergotamine-related adverse effects Details Dihydroergotamine Nasal Spray Phenylephrine Biorphen Increased risk of elevation of blood pressure Details Dihydroergotamine Nasal Spray Phenylpropanolamine Extreme elevation of blood pressure Details Dihydroergotamine Nasal Spray Posaconazole Noxafil Increased dihydroergotamine exposure and an increased risk of ergotism Details Dihydroergotamine Nasal Spray Propylhexedrine Extreme elevation of blood pressure Details Dihydroergotamine Nasal Spray Pseudoephedrine Afrinol® Extreme elevation of blood pressure Details Dihydroergotamine Nasal Spray Ribociclib Kisqali Increased dihydroergotamine exposure and an increased risk of dihydroergotamine-related adverse effects Details Dihydroergotamine Nasal Spray Ritonavir Norvir Increased ergot derivatives exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Dihydroergotamine Nasal Spray Rizatriptan Prolonged vasospastic reactions Details Dihydroergotamine Nasal Spray Saquinavir Increased ergot derivatives exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Dihydroergotamine Nasal Spray Saralasin Extreme elevation of blood pressure Details Dihydroergotamine Nasal Spray Sumatriptan Imitrex Increased risk of coronary artery vasospasm Details Dihydroergotamine Nasal Spray Telaprevir Increased dihydroergotamine exposure and an increased risk of dihydroergotamine-related adverse effects Details Dihydroergotamine Nasal Spray Telithromycin An increased risk of acute ergot toxicity Details Dihydroergotamine Nasal Spray Tipranavir Aptivus An increased risk of dihydroergotamine toxicity including nausea, vomiting, and vasospastic ischemia Details Dihydroergotamine Nasal Spray Troleandomycin Increased dihydroergotamine exposure and an increased risk of acute ergot toxicity (ergotism) Details Dihydroergotamine Nasal Spray Tucatinib Tukysa Increased dihydroergotamine exposure and an increased risk of dihydroergotamine-related adverse effects Details Dihydroergotamine Nasal Spray Vasopressin Vasostrict Increased risk of elevation of blood pressure Details Dihydroergotamine Nasal Spray Voriconazole Vfend Increased ergot derivative exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Dihydroergotamine Nasal Spray Zolmitriptan Zomig Prolonged vasospastic reactions Details

Major

Dihydroergotamine Nasal Spray Abametapir Increased exposure of CYP3A4 substrate Details Dihydroergotamine Nasal Spray Alefacept Decreased dihydroergotamine plasma concentrations Details Dihydroergotamine Nasal Spray Apalutamide Erleada Reduced CYP3A4 substrate exposure Details Dihydroergotamine Nasal Spray Aprepitant Aponvie Increased dihydroergotamine exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Dihydroergotamine Nasal Spray Asciminib Scemblix Increased CYP3A4 exposure and an increased risk of CYP3A4-related adverse reactions Details Dihydroergotamine Nasal Spray Avacopan Tavneos Increased exposure to CYP3A4 substrate Details Dihydroergotamine Nasal Spray Azithromycin AzaSite An increased risk of acute ergot toxicity (ergotism) Details Dihydroergotamine Nasal Spray Belzutifan Welireg Reduced CYP3A4 substrates with NTI exposure and reduced efficacy of CYP3A4 substrates with NTI Details Dihydroergotamine Nasal Spray Berotralstat Orladeyo Increased CYP3A4 substrate exposure and an increased CYP3A4 substrate-related adverse reactions Details Dihydroergotamine Nasal Spray Carbamazepine Carbatrol Reduced CYP3A4 substrate exposure and reduced efficacy of CYP3A4 substrate Details Dihydroergotamine Nasal Spray Ciprofloxacin Increased dihydroergotamine exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Dihydroergotamine Nasal Spray Clofazimine Increased dihydroergotamine exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Dihydroergotamine Nasal Spray Clotrimazole Aardora Anti-Fungal Maximum Strength Increased ergot derivatives exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Dihydroergotamine Nasal Spray Conivaptan Vaprisol Increased CYP3A substrate exposure Details Dihydroergotamine Nasal Spray Crizotinib Xalkori Increased dihydroergotamine exposure Details Dihydroergotamine Nasal Spray Dabrafenib Tafinlar Reduced sensitive CYP3A4 substrate exposure Details Dihydroergotamine Nasal Spray Daridorexant Increased CYP3A4 substrate with NTI exposure Details Dihydroergotamine Nasal Spray Dexfenfluramine Serotonin syndrome (confusion, mental status changes, diaphoresis, tremor, myoclonus, shivering, hyperreflexia, hypertension) Details

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