Dihydroergotamine Nasal Spray

157 interactions 472 cited references
Also sold as: Migranal Migranal® Nasal Spray Trudhesa Trudhesa® Nasal Spray
About Dihydroergotamine Nasal Spray

Dihydroergotamine is used to treat migraine headaches (severe, throbbing headaches that sometimes are accompanied by nausea and sensitivity to sound and light). Dihydroergotamine is in a class of medications called ergot alkaloids. It works by tightening blood vessels in the brain and by stopping the release of natural… Read the full Dihydroergotamine Nasal Spray drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Troleandomycin Adagrasib Tucatinib Almotriptan Zolmitriptan Vasopressin
62 Contraindicated 79 Major 16 Moderate
All (157) Contraindicated (62) Major (79) Moderate (16)

Moderate

Dihydroergotamine Nasal Spray Artemether Reduced CYP3A4 substrate exposure and reduced efficacy of CYP3A4 substrate Details Dihydroergotamine Nasal Spray Citalopram Celexa An increased risk of weakness, hyperreflexia and incoordination Details Dihydroergotamine Nasal Spray Escitalopram Lexapro An increased risk of weakness, hyperreflexia and incoordination Details Dihydroergotamine Nasal Spray Infliximab Avsola Decreased dihydroergotamine plasma concentrations Details Dihydroergotamine Nasal Spray Kratom Increased CYP3A substrate exposure Details Dihydroergotamine Nasal Spray Lapatinib Tykerb Increased exposure of dihydroergotamine Details Dihydroergotamine Nasal Spray Mavacamten Camzyos Reduced CYP3A4 substrate exposure and reduced efficacy of CYP3A4 substrate Details Dihydroergotamine Nasal Spray Metreleptin Altered exposure to dihydroergotamine Details Dihydroergotamine Nasal Spray Metronidazole Flagyl Increased plasma concentrations of ergot derivatives and increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Dihydroergotamine Nasal Spray Nitroglycerin Gonitro Dihydroergotamine toxicity (peripheral ischemia, paresthesias, nausea, vomiting) Details Dihydroergotamine Nasal Spray Paroxetine Paxil An increased risk of weakness, hyperreflexia and incoordination Details Dihydroergotamine Nasal Spray Rilonacept Altered dihydroergotamine plasma concentrations Details Dihydroergotamine Nasal Spray Rilzabrutinib Wayrilz Increased CYP3A substrate exposure and an increased risk of CYP3A substrate-related adverse reactions Details Dihydroergotamine Nasal Spray Sertraline An increased risk of weakness, hyperreflexia and incoordination Details Dihydroergotamine Nasal Spray Vilazodone Viibryd An increased risk of weakness, hyperreflexia and incoordination Details Dihydroergotamine Nasal Spray Vortioxetine Trintellix An increased risk of weakness, hyperreflexia and incoordination Details

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