Dihydroergotamine Nasal Spray

157 interactions 472 cited references

Also sold as: Migranal Migranal® Nasal Spray Trudhesa Trudhesa® Nasal Spray

About Dihydroergotamine Nasal Spray

Dihydroergotamine is used to treat migraine headaches (severe, throbbing headaches that sometimes are accompanied by nausea and sensitivity to sound and light). Dihydroergotamine is in a class of medications called ergot alkaloids. It works by tightening blood vessels in the brain and by stopping the release of natural… Read the full Dihydroergotamine Nasal Spray drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Troleandomycin Adagrasib Tucatinib Almotriptan Zolmitriptan Vasopressin

62 Contraindicated 79 Major 16 Moderate

All (157) Contraindicated (62) Major (79) Moderate (16)

Contraindicated

Dihydroergotamine Nasal Spray Adagrasib Krazati Increased dihydroergotamine exposure and an increased risk of dihydroergotamine-related adverse effects Details Dihydroergotamine Nasal Spray Almotriptan Increased risk of coronary artery vasospasm Details Dihydroergotamine Nasal Spray Amprenavir Increased dihydroergotamine exposure and an increased risk of ergotism (nausea, vomiting, peripheral vasospasm, and peripheral isc... Details Dihydroergotamine Nasal Spray Atazanavir Reyataz An increased risk of peripheral vasospasm and ischemia of the extremities and other tissues Details Dihydroergotamine Nasal Spray Boceprevir Increased dihydroergotamine exposure and an increased risk of dihydroergotamine-related adverse effects Details Dihydroergotamine Nasal Spray Bromocriptine Cycloset An increased risk of ergotism Details Dihydroergotamine Nasal Spray Ceritinib Zykadia Increased dihydroergotamine exposure and an increased risk of dihydroergotamine-related adverse effects Details Dihydroergotamine Nasal Spray Clarithromycin Biaxin Increased dihydroergotamine exposure and an increased risk of acute ergot toxicity (ergotism) Details Dihydroergotamine Nasal Spray Cobicistat Tybost An increased risk of acute ergot toxicity (peripheral vasospasm, ischemia of the extremities) Details Dihydroergotamine Nasal Spray Darunavir An increased risk of acute ergot toxicity (peripheral vasospasm, ischemia of the extremities) Details Dihydroergotamine Nasal Spray Delavirdine Rescriptor® Increased dihydroergotamine exposure and an increased risk of ergot toxicity (vasospastic ischemia) Details Dihydroergotamine Nasal Spray Dobutamine Increased risk of elevation of blood pressure Details Dihydroergotamine Nasal Spray Dopamine Increased risk of elevation of blood pressure Details Dihydroergotamine Nasal Spray Eletriptan Relpax Increased risk of prolonged vasospastic reactions Details Dihydroergotamine Nasal Spray Ensitrelvir Increased ergot derivatives exposure; an increased risk of ergot derivatives-related toxicity Details Dihydroergotamine Nasal Spray Ephedrine Increased risk of elevation of blood pressure Details Dihydroergotamine Nasal Spray Epinephrine Increased risk of elevation of blood pressure Details Dihydroergotamine Nasal Spray Ergoloid Mesylates Alkergot® An increased risk of ergotism Details Dihydroergotamine Nasal Spray Ergonovine An increased risk of ergotism Details Dihydroergotamine Nasal Spray Ergotamine Ergomar An increased risk of ergotism Details Dihydroergotamine Nasal Spray Erythromycin Erythrocin Stearate Increased dihydroergotamine exposure and an increased risk of acute ergot toxicity (ergotism) Details Dihydroergotamine Nasal Spray Fosamprenavir Lexiva Increased dihydroergotamine exposure and an increased risk of ergotism (nausea, vomiting, peripheral vasospasm, and peripheral isc... Details Dihydroergotamine Nasal Spray Frovatriptan Frova Prolonged vasospastic reactions Details Dihydroergotamine Nasal Spray Idelalisib Zydelig Increased dihydroergotamine exposure and an increased risk of acute ergot toxicity Details Dihydroergotamine Nasal Spray Indinavir Increased ergot derivative exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Dihydroergotamine Nasal Spray Itraconazole Sporanox An increased risk of ergotism (vasospasm leading to cerebral ischemia and/or ischemia of the extremities) Details Dihydroergotamine Nasal Spray Ketoconazole Extina Increased ergot derivatives exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Dihydroergotamine Nasal Spray Letermovir Prevymis Increased ergot alkaloids exposure and an increased risk of ergotism Details Dihydroergotamine Nasal Spray Levoketoconazole Recorlev Increased CYP3A4 substrate exposure and an increased risk of sensitive CYP3A4 substrate-related adverse reaction Details Dihydroergotamine Nasal Spray Lisuride An increased risk of ergotism Details Dihydroergotamine Nasal Spray Lonafarnib Zokinvy Increased dihydroergotamine exposure and an increased risk of dihydroergotamine-related adverse effects Details Dihydroergotamine Nasal Spray Lopinavir An increased risk of dihydroergotamine toxicity including nausea, vomiting, and vasospastic ischemia Details Dihydroergotamine Nasal Spray Metergoline An increased risk of ergotism Details Dihydroergotamine Nasal Spray Methylergonovine Methergine An increased risk of ergotism Details Dihydroergotamine Nasal Spray Methysergide An increased risk of ergotism Details Dihydroergotamine Nasal Spray Mifepristone Korlym Increased dihydroergotamine exposure and risk of adverse events Details Dihydroergotamine Nasal Spray Naratriptan Prolonged vasospastic reactions Details Dihydroergotamine Nasal Spray Nefazodone Increased ergot derivatives exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Dihydroergotamine Nasal Spray Nelfinavir Viracept Increased dihydroergotamine exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Dihydroergotamine Nasal Spray Nicergoline An increased risk of ergotism Details

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