Dihydroergotamine

Name: Dihydroergotamine Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

30 interactions 2 explained in plain English

Also sold as: Brekiya Migranal Trudhesa

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Dopamine Dobutamine Methylergonovine Letermovir Injection Ketoconazole Topical Octreotide Injection

5 Contraindicated 15 Major 10 Moderate

All (30) Contraindicated (5) Major (15) Moderate (10)

Contraindicated

Dihydroergotamine Dobutamine Increased risk of elevation of blood pressure Details Dihydroergotamine Dopamine Increased risk of elevation of blood pressure Details Dihydroergotamine Ketoconazole Topical Extina® Foam Increased ergot derivatives exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Dihydroergotamine Letermovir Injection Prevymis Increased ergot alkaloids exposure and an increased risk of ergotism Details Dihydroergotamine Methylergonovine Methergine An increased risk of ergotism Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.