Dihydroergotamine

30 interactions 2 explained in plain English
Also sold as: Brekiya Migranal Trudhesa
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Dopamine Dobutamine Methylergonovine Letermovir Injection Ketoconazole Topical Octreotide Injection
5 Contraindicated 15 Major 10 Moderate
All (30) Contraindicated (5) Major (15) Moderate (10)

Moderate

Dihydroergotamine Sertraline Explained An increased risk of weakness, hyperreflexia and incoordination Details Dihydroergotamine Metronidazole Flagyl Increased plasma concentrations of ergot derivatives and increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Dihydroergotamine Metronidazole Injection Flagyl Increased plasma concentrations of ergot derivatives and increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Dihydroergotamine Metronidazole Topical MetroCream® Increased plasma concentrations of ergot derivatives and increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Dihydroergotamine Metronidazole Vaginal MetroGel® Vaginal Increased plasma concentrations of ergot derivatives and increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Dihydroergotamine Nitroglycerin Gonitro Dihydroergotamine toxicity (peripheral ischemia, paresthesias, nausea, vomiting) Details Dihydroergotamine Nitroglycerin Spray Nitrolingual Dihydroergotamine toxicity (peripheral ischemia, paresthesias, nausea, vomiting) Details Dihydroergotamine Nitroglycerin Sublingual Nitrostat Dihydroergotamine toxicity (peripheral ischemia, paresthesias, nausea, vomiting) Details Dihydroergotamine Nitroglycerin Topical Nitro-Bid Dihydroergotamine toxicity (peripheral ischemia, paresthesias, nausea, vomiting) Details Dihydroergotamine Nitroglycerin Transdermal Patch Minitran® Patch Dihydroergotamine toxicity (peripheral ischemia, paresthesias, nausea, vomiting) Details

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