Diphenhydramine Injection

123 interactions 540 cited references
Also sold as: Banophen Benadryl Calagel Reformulated Jun 2019 Compoz Dermamycin Diphedryl Diphenhist Dormin Genahist Kids-Eeze Allergy Nytol Pediaclear Cough Rest Simply Scot-Tussin Allergy Siladryl Simply Sleep Sleep-Eze Sleepinal Sominex Somnapure The Itch Eraser Twilite Unisom Sleep Vanamine Vetadryl Wal-Dryl Allergy Wal-Dryl Childrens Wal-Sleep Z Wal-Som Wal-Som Maximum Strength Z-Sleep ZZZ Sleep Zzzquil
About Diphenhydramine Injection

Diphenhydramine injection is an antihistamine used to treat allergic reactions, motion sickness, and abnormal movements in Parkinsonian syndrome. Read the full Diphenhydramine Injection drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Potassium Oxybate Potassium Citrate Potassium Chloride Magnesium Oxybate Isocarboxazid Calcium Oxybate
8 Contraindicated 102 Major 11 Moderate 2 Minor
All (123) Contraindicated (8) Major (102) Moderate (11) Minor (2)

Contraindicated

Diphenhydramine Injection Calcium Oxybate Xywav An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Diphenhydramine Injection Isocarboxazid Marplan An increased risk of CNS depression Details Diphenhydramine Injection Magnesium Oxybate Xywav An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Diphenhydramine Injection Potassium Chloride K-Tab Increased risk of gastrointestinal irritation Details Diphenhydramine Injection Potassium Citrate Urocit-K Increased risk of gastrointestinal irritation Details Diphenhydramine Injection Potassium Oxybate Xywav An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Diphenhydramine Injection Sodium Oxybate Lumryz An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Diphenhydramine Injection Tranylcypromine Parnate Increased risk of anticholinergic effects and an increased risk of CNS depression Details

Major

Diphenhydramine Injection Alfentanil An increased risk of respiratory and CNS depression and an increased risk of paralytic ileus Details Diphenhydramine Injection Alprazolam Xanax Increased risk of CNS depression Details Diphenhydramine Injection Amantadine Potentiation of anticholinergic effects Details Diphenhydramine Injection Amifampridine Increased risk of seizures Details Diphenhydramine Injection Benzhydrocodone Increased risk of urinary retention and/or severe constipation leading to paralytic ileus and an increased risk of respiratory dep... Details Diphenhydramine Injection Bromazepam Increased risk of respiratory or cardiovascular depression Details Diphenhydramine Injection Bromopride Potentiation of sedative effects Details Diphenhydramine Injection Buprenorphine Belbuca An increased risk of respiratory and CNS depression and an increased risk of paralytic ileus Details Diphenhydramine Injection Bupropion Aplenzin Increased risk of seizures Details Diphenhydramine Injection Butalbital An increased risk of CNS depression Details Diphenhydramine Injection Butorphanol Butorphic Increased risk of respiratory and CNS depression Details Diphenhydramine Injection Cannabidiol Epidiolex Increased risk of CNS depression and an increased risk of sedation and somnolence Details Diphenhydramine Injection Cannabis An increased risk of CNS depression Details Diphenhydramine Injection Carbamazepine Carbatrol An increased risk of CNS depression Details Diphenhydramine Injection Carbidopa Lodosyn An increased risk of CNS depression Details Diphenhydramine Injection Carbinoxamine Carbzah An increased risk of CNS depression Details Diphenhydramine Injection Cetirizine Aller-Tec Increased risk of CNS depression Details Diphenhydramine Injection Clobazam Onfi Increased risk of sedation Details Diphenhydramine Injection Clomipramine Anafranil Increased clomiPRAMINE exposure, an increased risk of CNS depression, increased anticholinergic effects (dry mouth, urinary retent... Details Diphenhydramine Injection Clonazepam Klonopin Increased risk of CNS depression Details Diphenhydramine Injection Clozapine Clozaril Increased risk of anticholinergic toxicity and gastrointestinal adverse reactions Details Diphenhydramine Injection Codeine Tuzistra XR® (as a combination product containing Chlorpheniramine, Codeine) Increased risk of paralytic ileus and an increased risk of respiratory and CNS depression Details Diphenhydramine Injection Cyclobenzaprine Amrix An increased risk of atropine-like adverse reactions and an increased risk of CNS depression Details Diphenhydramine Injection Cyproheptadine An increased risk of CNS depression Details Diphenhydramine Injection Daridorexant An increased risk CNS depression Details Diphenhydramine Injection Dexmedetomidine Dexased Increased risk of CNS depression Details Diphenhydramine Injection Dextroamphetamine Dexedrine Increased dextroamphetamine or lisdexamfetamine (prodrug of dextroamphetamine) exposure and an increased risk of serotonin syndrom... Details Diphenhydramine Injection Diazepam Diastat Increased risk of CNS depression Details Diphenhydramine Injection Dihydrocodeine Increased risk of paralytic ileus and an increased risk of respiratory and CNS depression Details Diphenhydramine Injection Donepezil Adlarity Reduced seizure threshold Details Diphenhydramine Injection Doxepin Prudoxin An increased risk of CNS depression Details Diphenhydramine Injection Doxylamine Aldex AN Increased risk of CNS depression Details

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