Dipyrone
116 interactions 8 explained in plain English
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Ketorolac Nasal Spray
Ketorolac Ophthalmic
Ketorolac Injection
Ketorolac
Pemetrexed Injection
Cyclosporine Ophthalmic
Contraindicated
Dipyrone Ketorolac Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Dipyrone Ketorolac Injection Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Dipyrone Ketorolac Nasal Spray Sprix Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Dipyrone Ketorolac Ophthalmic Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) DetailsMajor
Dipyrone Acetaminophen And Codeine Capital® & Codeine Explained Reduced codeine and morphine exposure, reduced opioid efficacy and precipitation of opioid withdrawal Details Dipyrone Amitriptyline Elavil Explained An increased risk of bleeding Details Dipyrone Sertraline Explained An increased risk of bleeding and a reduced sertraline exposure Details Dipyrone Buprenorphine Belbuca Explained Reduced buprenorphine exposure and reduced efficacy of buprenorphine Details Dipyrone Apixaban Eliquis Explained An increased risk of bleeding Details Dipyrone Aspirin Acuprin® Reduced efficacy of aspirin, an increased risk of bleeding, and decreased renal function Details Dipyrone Aspirin Rectal Aspirin Reduced efficacy of aspirin, an increased risk of bleeding, and decreased renal function Details Dipyrone Atogepant Qulipta Reduced atogepant exposure Details Dipyrone Avapritinib Ayvakit Reduced avapritinib exposure and reduced efficacy of avapritinib Details Dipyrone Betrixaban Bevyxxa® An increased risk of bleeding Details Dipyrone Cariprazine Vraylar Explained Effects on the cariprazine exposure has not been evaluated and the net effect is unclear Details Dipyrone Aficamten Reduced aficamten exposure and reduced efficacy of aficamten Details Dipyrone Amlodipine Amvaz® Reduced amLODIPine exposure Details Dipyrone Anagrelide Agrylin An increased risk of bleeding Details Dipyrone Bedaquiline Sirturo Reduced bedaquiline exposure and reduced efficacy of bedaquiline Details Dipyrone Bromfenac Ophthalmic Bromday® Increased risk of bleeding Details Dipyrone Budesonide Entocort Increased risk of gastrointestinal ulcer or bleeding Details Dipyrone Budesonide Nasal Spray Rhinocort Increased risk of gastrointestinal ulcer or bleeding Details Dipyrone Budesonide Oral Inhalation Pulmicort Increased risk of gastrointestinal ulcer or bleeding Details Dipyrone Cabozantinib Cabometyx Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Dipyrone Cabozantinib (Thyroid Cancer) Cabometyx Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Dipyrone Clopidogrel Plavix An increased risk of bleeding Details Dipyrone Cyclosporine Injection Atopica An increased risk of cycloSPORINE nephrotoxicity Details Dipyrone Cyclosporine Ophthalmic Cequa An increased risk of cycloSPORINE nephrotoxicity Details Dipyrone Dabigatran Pradaxa® An increased risk of bleeding Details Dipyrone Dabigatran Etexilate An increased risk of bleeding Details Dipyrone Dalteparin Injection Fragmin An increased risk of bleeding Details Dipyrone Deflazacort Emflaza Increased risk of gastrointestinal ulcer or bleeding Details Dipyrone Dexamethasone Injection Decadron Increased risk of gastrointestinal ulcer or bleeding Details Dipyrone Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Increased risk of gastrointestinal ulcer or bleeding Details Dipyrone Diclofenac Ophthalmic Voltaren® Eye Drops Increased risk of bleeding Details Dipyrone Diclofenac Topical (Actinic Keratosis) Pennsaid Increased risk of bleeding Details Dipyrone Diclofenac Topical (Arthritis Pain) Pennsaid® Increased risk of bleeding Details Dipyrone Diclofenac Transdermal Patch Flector Increased risk of bleeding Details Dipyrone Digoxin Cardoxin® Increased digoxin exposure and prolonged half-life of digoxin Details Dipyrone Dipyridamole Permole® An increased risk of bleeding DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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