Dipyrone and Benazepril: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Jul 15, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Dipyrone
No brand names on recordBenazepril
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure
Interaction Deep Dive
NSAIDs may decrease the antihypertensive and natriuretic effect of ACE inhibitors or angiotensin receptor blockers (ARBs). Additionally, coadministration may result in deterioration of renal function, including possible acute renal failure, in some patients. When concomitant use is required, determine the need to monitor renal function at initiation of treatment, monitor for antihypertensive efficacy, and assess renal function periodically for signs of renal deterioration or failure, especially in patients who are elderly, during treatment initiation, in the volume-depleted, or those with preexisting renal dysfunction. Ensure that patients are adequately hydrated1234.
Why it happens (mechanism)
Additive effects on renal function; decreased renal prostaglandin production
Literature reports
4 reports — tap to read
a) Four days after initiation of indomethacin 100 mg/day for gout, a 48-year-old man with hypertension who was previously well-controlled with enalapril 10 mg/day experienced severe hypertension, psychosis, disorientation, and generalized anasarca 5. Hypertension was not controlled with an enalapril dose increase to 20 mg/day, and indomethacin was discontinued. One day later, the patient experienced rapid diuresis and significant weight loss. The enalapril dose was then reduced to 10 mg/day with good control of hypertension and no residual psychosis 6.
b) Indomethacin antagonized the antihypertensive effect of captopril in a randomized, double-blind, parallel-design multicenter study involving 141 hypertensive patients. One week of concomitant therapy with indomethacin and captopril increased 24-hour systolic blood pressure by 4.6 mmHg and diastolic by 2.7 mmHg (p less than 0.001). Overall, ambulatory diastolic blood pressure rose in 67% of patients treated with captopril during indomethacin treatment 7.
c) Hypertension worsened in a 59-year-old man treated for 5 years with lisinopril 10 mg/day after rofecoxib 25/day for arthritic pain was initiated. After 5 weeks, blood pressure increased from 130 to 135/80 to 85 to 168/98. Rofecoxib was withdrawn. Blood pressure declined over the following 18 days (average, 127/78 mmHg). Rofecoxib was restarted at 25 mg/day due to increased joint pain. After 2 days of therapy, blood pressure increased, and over the next 2 weeks it averaged 143/89 mmHg. Lisinopril was increased to 20 mg/day, resulting in an average blood pressure of 121/81 mmHg over the next 21 days 8.
d) Celecoxib did not attenuate the antihypertensive effect of lisinopril in 178 hypertensive patients in a double-blind, placebo-controlled, parallel-group trial. Patients received celecoxib 200 mg twice daily or placebo in addition to their usual lisinopril therapy (10 to 40 mg daily) for 4 weeks. Changes from baseline in the 24-hour systolic and diastolic blood pressure (BP) were nonsignificant. The proportion of patients whose 24-hour BP increased by at least 5, 10, 15, or 20 mmHg were also similar on celecoxib and placebo. The placebo-subtracted changes observed in 24-hour BP (1.6/1.2 mmHg) were less than what has been reported for NSAIDs in ACE inhibitor-treated patients 9.
Common questions
Can I take Dipyrone and Benazepril together?
Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Always confirm with your pharmacist or prescriber before making any change.
How serious is the Dipyrone and Benazepril interaction?
It is rated moderate. Can be significant — usually manageable with monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "established". Well documented — supported by controlled studies or strong clinical data.
From our Q&A
Real reader questions about these medications, each personally answered by our pharmacist:
Questions for your pharmacist
- Does my dose of Dipyrone or Benazepril need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there anything you'd monitor while I'm on both?
References (9)
- Product Information: Dynastat intravenous injection, intramuscular injection, parecoxib sodium intravenous injection, intramuscular injection. Pfizer Australia Pty Ltd (per Australian Register of Therapeutic Goods), West Ryde, Australia, 2017. DailyMed
- Product Information: SPRIX(R) nasal spray, ketorolac tromethamine nasal spray. Egalet US Inc. (per FDA), Wayne, PA, 2016. DailyMed
- Product Information: CALDOLOR(R) intravenous injection, ibuprofen intravenous injection. Cumberland Pharmaceuticals Inc. (per FDA), Nashville, TN, 2016. DailyMed
- Product Information: meloxicam oral tablets, meloxicam oral tablets. Apotex Corp. (per DailyMed), Weston, FL, 2016. DailyMed
- Ahmad S: Indomethacin-enalapril interaction: an alert (letter). South Med J 1991; 84:411-412. PubMed
- Morgan T, Anderson A, & Bertram D: Effect of indomethacin on blood pressure in elderly people with essential hypertension well controlled on amlodipine or enalapril. Am J Hypertens 2000; 13:1161-1167. PubMed
- Conlin P, Moore T, Swartz S, et al: Effect of indomethacin on blood pressure lowering by captopril and losartan in hypertensive patients. Hypertension 2000; 36:461-465. PubMed
- Brown C: Effect of rofecoxib on the antihypertensive activity of lisinopril (letter). Ann Pharmacother 2000; 34:1486. PubMed
- White W, Kent J, Taylor A, et al: Effects of celecoxib on ambulatory blood pressure in hypertensive patients on ACE inhibitors. Hypertension 2002; 39:929-934. PubMed
Keep reading about Dipyrone
Keep reading about Benazepril
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Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
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