Dipyrone and Ofloxacin Otic: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Dipyrone
No brand names on recordOfloxacin Otic
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
An increased risk of seizures
Interaction Deep Dive
The concurrent administration of ofloxacin, a quinolone antibiotic, and an NSAID may increase the risk of central nervous system stimulation and convulsive seizures. This risk may be compounded in patients predisposed to seizure activity1.
Why it happens (mechanism)
Inhibition of gamma aminobutyric acid (GABA) resulting in central nervous system stimulation
Common questions
Can I take Dipyrone and Ofloxacin Otic together?
An increased risk of seizures Always confirm with your pharmacist or prescriber before making any change.
How serious is the Dipyrone and Ofloxacin Otic interaction?
It is rated moderate. Can be significant — usually manageable with monitoring.
How quickly could this interaction happen?
The documented onset is "delayed". Effects tend to build up gradually over days to weeks.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Dipyrone or Ofloxacin Otic need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there anything you'd monitor while I'm on both?
References (1)
- Product Information: Floxin(R), ofloxacin. Ortho-McNeil Pharmaceutical, Inc. aritan, NJ, 2000. DailyMed
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