Disopyramide and Fingolimod: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Fingolimod
Disopyramide
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased risk of QT interval prolongation, bradycardia, or heart block
Interaction Deep Dive
Disopyramide, a class IA antiarrhythmic agent, has the potential to cause heart block, QT interval prolongation, and cardiac arrhythmias1. Bradycardia and atrioventricular block have occurred after the first dose of fingolimod; prolongation of the QT interval has also been reported. A patient receiving disopyramide who is initiated on fingolimod may have an increased risk of developing bradycardia, heart block, QT interval prolongation, and torsade de pointes due to additive cardiac effects. The concomitant use of disopyramide and fingolimod is contraindicated 2.
Why it happens (mechanism)
Additive QT-prolongation; additive cardiac effects
Common questions
Can I take Disopyramide and Fingolimod together?
Increased risk of QT interval prolongation, bradycardia, or heart block Always confirm with your pharmacist or prescriber before making any change.
How serious is the Disopyramide and Fingolimod interaction?
It is rated contraindicated. These should generally not be used together.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Disopyramide or Fingolimod need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (2)
- Product Information: NORPACE(R), NORPACE(R) CR oral capsules, extended-release capsules, disopyramide phosphate oral capsules, extended-release capsules. G.D. Searle LLC, Chicago, IL, 2006. DailyMed
- Product Information: GILENYA(TM) oral capsules, fingolimod oral capsules. Novartis Pharmaceuticals Corporation (Per Manufacturer), East Hanover, NJ, 2012. DailyMed
Keep reading about Fingolimod
Keep reading about Disopyramide
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
Check another combination
Our instant two-drug interaction checker is almost here.
Still have questions about this combination?
Every question gets a real answer from a licensed pharmacist — free, and usually within a day.
Ask the pharmacist