Disopyramide

284 interactions 642 cited references

Also sold as: Norpace Norpace® Norpace® CR

About Disopyramide

Disopyramide is used to treat certain types of irregular heartbeats). Disopyramide is in a class of medications called antiarrhythmic medications. It works by making your heart more resistant to abnormal activity. Read the full Disopyramide drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Levomethadyl Levoketoconazole Mesoridazine Itraconazole Pimozide Piperaquine

15 Contraindicated 247 Major 22 Moderate

All (284) Contraindicated (15) Major (247) Moderate (22)

Contraindicated

Disopyramide Bepridil An increased risk of QT interval prolongation Details Disopyramide Cisapride Propulsid® Increased risk of QT interval prolongation Details Disopyramide Dronedarone Multaq Increased risk of QT interval prolongation Details Disopyramide Fingolimod Gilenya Increased risk of QT interval prolongation, bradycardia, or heart block Details Disopyramide Itraconazole Sporanox Increased disopyramide exposure and an increased risk of cardiotoxicity (eg, QT interval prolongation, torsades de pointes, cardia... Details Disopyramide Levoketoconazole Recorlev An increased risk of QT interval prolongation and torsades pointes, an increased CYP3A4 substrate exposure and an increased risk o... Details Disopyramide Levomethadyl An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Disopyramide Mesoridazine An increased risk of QT interval prolongation Details Disopyramide Pimozide An increased risk of QT interval prolongation Details Disopyramide Piperaquine An increased risk of QT interval prolongation Details Disopyramide Sparfloxacin An increased risk of QT interval prolongation Details Disopyramide Terfenadine An increased risk of QT interval prolongation Details Disopyramide Thioridazine An increased risk of QT interval prolongation Details Disopyramide Vernakalant Increased risk of atrial flutter and other cardiovascular events Details Disopyramide Ziprasidone Geodon Increased risk of QT interval prolongation Details

Major

Disopyramide Amitriptyline Elavil An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Disopyramide Sertraline An increased risk of QT interval prolongation Details Disopyramide Buprenorphine Belbuca An increased risk of QT interval prolongation Details Disopyramide Relugolix Orgovyx Increased risk of QT interval prolongation Details Disopyramide Amisulpride Injection Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Disopyramide Arsenic Trioxide Trisenox An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Disopyramide Aripiprazole Injection Abilify An increased risk of QT interval prolongation Details Disopyramide Arsenic Trioxide Injection Trisenox An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Disopyramide Asenapine Transdermal Patch Secuado Increased risk of QT interval prolongation Details Disopyramide Azithromycin AzaSite An increased risk of QT interval prolongation and serious cardiac arrhythmias Details Disopyramide Alfuzosin UroXatral An increased risk of QT interval prolongation Details Disopyramide Anagrelide Agrylin Increased risk of QT interval prolongation Details Disopyramide Bedaquiline Sirturo Increased risk of QT interval prolongation Details Disopyramide Betaxolol Betoptic S Severe bradycardia, asystole and heart failure Details Disopyramide Betaxolol Ophthalmic Betoptic® Severe bradycardia, asystole and heart failure Details Disopyramide Chloroquine Aralen® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Disopyramide Dasatinib Phyrago An increased risk of QT interval prolongation Details Disopyramide Degarelix Injection Firmagon Increased risk of QT interval prolongation Details Disopyramide Deutetrabenazine Austedo An increased risk of QT interval prolongation Details Disopyramide Adagrasib Krazati An increased risk of QT interval prolongation, torsade de pointes, polymorphic ventricular tachycardia, other serious arrhythmias Details Disopyramide Ajmaline An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Disopyramide Amiodarone Nexterone Increased antiarrhythmic levels, QTc prolongation Details Disopyramide Amisulpride Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Disopyramide Amoxapine An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Disopyramide Apomorphine Apokyn An increased risk of QT interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.