Disopyramide

284 interactions 642 cited references

Also sold as: Norpace Norpace® Norpace® CR

About Disopyramide

Disopyramide is used to treat certain types of irregular heartbeats). Disopyramide is in a class of medications called antiarrhythmic medications. It works by making your heart more resistant to abnormal activity. Read the full Disopyramide drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Levomethadyl Levoketoconazole Mesoridazine Itraconazole Pimozide Piperaquine

15 Contraindicated 247 Major 22 Moderate

All (284) Contraindicated (15) Major (247) Moderate (22)

Major

Disopyramide Clomipramine Anafranil An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Disopyramide Clothiapine Increased risk of cardiac arrhythmias Details Disopyramide Clozapine Clozaril Increased risk of QT interval prolongation Details Disopyramide Cobicistat Tybost Increased disopyramide exposure Details Disopyramide Crizotinib Xalkori An increased risk of QT interval prolongation Details Disopyramide Cyclobenzaprine Amrix An increased risk of QT interval prolongation Details Disopyramide Dabrafenib Tafinlar An increased risk of QT interval prolongation Details Disopyramide Dasabuvir Increased plasma concentration of antiarrhythmic agent Details Disopyramide Degarelix Firmagon Increased risk of QT interval prolongation Details Disopyramide Delamanid Increased risk of QT interval prolongation Details Disopyramide Desflurane Suprane An increased risk of QT interval prolongation Details Disopyramide Desipramine Norpramin An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Disopyramide Dexmedetomidine Dexased Increased risk of cardiac arrhythmias Details Disopyramide Dofetilide Tikosyn An increased risk of QT interval prolongation and an increased risk of torsades de pointes Details Disopyramide Dolasetron Anzemet Cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Disopyramide Domperidone Increased risk of QT interval prolongation Details Disopyramide Donepezil Adlarity Increased risk of QT-interval prolongation and torsade de pointes Details Disopyramide Dordaviprone An increased risk of QT interval prolongation Details Disopyramide Doxepin Prudoxin An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Disopyramide Droperidol An increased risk of QT interval prolongation Details Disopyramide Efavirenz An increased risk of QT interval prolongation Details Disopyramide Eliglustat Cerdelga Increased risk of cardiac arrhythmias Details Disopyramide Encorafenib Braftovi Increased risk of QT interval prolongation Details Disopyramide Enflurane An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Disopyramide Entrectinib Rozlytrek An increased risk of QT interval prolongation Details Disopyramide Epinephrine An increased risk of cardiac arrhythmias Details Disopyramide Erythromycin Erythrocin Stearate Increased disopyramide exposure, an increased risk of disopyramide-related adverse effects and an increased risk of QT interval pr... Details Disopyramide Escitalopram Lexapro An increased risk of QT interval prolongation Details Disopyramide Etrasimod Velsipity Increased risk of transient reduction in heart rate, AV conduction, QT interval prolongation and an increased risk of torsade de p... Details Disopyramide Etravirine Intelence Decreased disopyramide plasma concentrations Details Disopyramide Fexinidazole An increased risk of QT interval prolongation Details Disopyramide Flecainide Tambocor® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Disopyramide Fluconazole Diflucan An increased risk of QT interval prolongation Details Disopyramide Fluoxetine RECONCILE An increased risk of QT interval prolongation and an increased risk of torsades de pointes Details Disopyramide Formoterol Perforomist Increased risk of QT interval prolongation and an increased risk of cardiovascular adverse effects Details Disopyramide Foscarnet Foscavir An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Disopyramide Fosfomycin Contepo An increased risk of QT interval prolongation Details Disopyramide Fosphenytoin Cerebyx Reduced disopyramide exposure and an increased risk of QT interval prolongation Details Disopyramide Fostemsavir Rukobia Increased risk of torsade de pointes Details Disopyramide Gatifloxacin Zymaxid An increased risk of QT interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.