Disopyramide

284 interactions 642 cited references

Also sold as: Norpace Norpace® Norpace® CR

About Disopyramide

Disopyramide is used to treat certain types of irregular heartbeats). Disopyramide is in a class of medications called antiarrhythmic medications. It works by making your heart more resistant to abnormal activity. Read the full Disopyramide drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Levomethadyl Levoketoconazole Mesoridazine Itraconazole Pimozide Piperaquine

15 Contraindicated 247 Major 22 Moderate

All (284) Contraindicated (15) Major (247) Moderate (22)

Major

Disopyramide Gemifloxacin Factive An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Disopyramide Gepirone Exxua An increased risk of QT interval prolongation and cardiac arrhythmias Details Disopyramide Gepotidacin Blujepa An increased risk of QT interval prolongation Details Disopyramide Givinostat Duvyzat Increased risk of QT interval prolongation and torsade de pointes Details Disopyramide Glasdegib Daurismo Increased risk of QT interval prolongation Details Disopyramide Glimepiride Amaryl Increased risk of hypoglycemia Details Disopyramide Glipizide Glucotrol Increased risk of hypoglycemia Details Disopyramide Glyburide DiaBeta® Increased risk of hypoglycemia Details Disopyramide Goserelin Increased risk of QT interval prolongation Details Disopyramide Granisetron An increased risk of QT interval prolongation Details Disopyramide Halofantrine An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Disopyramide Haloperidol An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Disopyramide Halothane An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Disopyramide Histrelin Supprelin Increased risk of QT interval prolongation Details Disopyramide Hydroquinidine An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Disopyramide Hydroxychloroquine Plaquenil Increased risk of QT interval prolongation Details Disopyramide Hydroxyzine An increased risk of QT interval prolongation Details Disopyramide Ibutilide Corvert An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Disopyramide Iloperidone Fanapt An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Disopyramide Imipramine An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Disopyramide Inotuzumab Ozogamicin Besponsa Increased risk of QT interval prolongation Details Disopyramide Insulin Icodec-Abae Awiqli Increased risk of hypoglycemia Details Disopyramide Isoflurane Fluriso An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Disopyramide Isradipine DynaCirc® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Disopyramide Ivabradine Corlanor Increased risk of QT prolongation Details Disopyramide Ivosidenib Tibsovo An increased risk of QT interval prolongation Details Disopyramide Ketoconazole Extina Increased risk for QT interval prolongation Details Disopyramide Lacosamide Motpoly An increased risk of AV block, bradycardia, and ventricular tachyarrhythmia Details Disopyramide Lapatinib Tykerb An increased risk of QT interval prolongation Details Disopyramide Lefamulin Xenleta Increased risk of QT interval prolongation Details Disopyramide Lenvatinib Lenvima Increased risk of QT-interval prolongation Details Disopyramide Leuprolide Eligard Increased risk of QT interval prolongation Details Disopyramide Levofloxacin Levaquin Increased risk of QT interval prolongation Details Disopyramide Lidocaine Akten An increased risk of cardiotoxicity Details Disopyramide Lidoflazine An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Disopyramide Lofexidine Increased risk of QT interval prolongation Details Disopyramide Lonafarnib Zokinvy An increased risk of QT interval prolongation and torsade de pointes Details Disopyramide Loperamide Diamode An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Disopyramide Lorcainide An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Disopyramide Lumefantrine An increased risk of QT interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.