Disopyramide

284 interactions 642 cited references

Also sold as: Norpace Norpace® Norpace® CR

About Disopyramide

Disopyramide is used to treat certain types of irregular heartbeats). Disopyramide is in a class of medications called antiarrhythmic medications. It works by making your heart more resistant to abnormal activity. Read the full Disopyramide drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Levomethadyl Levoketoconazole Mesoridazine Itraconazole Pimozide Piperaquine

15 Contraindicated 247 Major 22 Moderate

All (284) Contraindicated (15) Major (247) Moderate (22)

Major

Disopyramide Macimorelin Increased risk of QT interval prolongation Details Disopyramide Mavacamten Camzyos An increased risk of additive inotropic effects and reduced cardiac contractility Details Disopyramide Mavorixafor Xolremdi An increased risk of QT interval prolongation and torsade de pointes Details Disopyramide Mefloquine Lariam® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Disopyramide Methadone Diskets Increased QT interval prolongation Details Disopyramide Metronidazole Flagyl An increased risk of QT interval prolongation Details Disopyramide Mexiletine Mexitil® Disopyramide toxicity (cardiac arrhythmias, hypotension, syncope) and an increased risk of cardiotoxicity (QT prolongation, torsad... Details Disopyramide Mifepristone Korlym Increased disopyramide exposure and an increased risk of QT interval prolongation Details Disopyramide Milsaperidone An increased risk of QT interval prolongation Details Disopyramide Mirtazapine Mirataz Increased risk of QT interval prolongation and torsades de pointes Details Disopyramide Mobocertinib Exkivity An increased risk of QT interval prolongation Details Disopyramide Moxifloxacin Avelox Increased risk of QT interval prolongation Details Disopyramide Nalidixic Acid Increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Disopyramide Nelfinavir Viracept Increased risk of QT interval prolongation Details Disopyramide Nilotinib An increased risk of QT interval prolongation Details Disopyramide Nirmatrelvir Increased disopyramide exposure and potential toxicity (anticholinergic effects, hypotension, heart failure, cardiac arrhythmias) Details Disopyramide Norfloxacin An increased risk of QT interval prolongation Details Disopyramide Nortriptyline An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Disopyramide Octreotide Bynfezia An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Disopyramide Ofloxacin Floxin® An increased risk of QT interval prolongation Details Disopyramide Olanzapine An increased risk of QT interval prolongation Details Disopyramide Olodaterol Striverdi An increased risk of QT interval prolongation and an increased risk of ventricular arrhythmias Details Disopyramide Ombitasvir Increased concentration of the antiarrhythmic agent Details Disopyramide Ondansetron An increased risk of QT interval prolongation Details Disopyramide Osilodrostat Isturisa Increased risk of QT interval prolongation Details Disopyramide Osimertinib Tagrisso Increased risk of QT interval prolongation Details Disopyramide Oxaliplatin Increased risk of QT-interval prolongation Details Disopyramide Ozanimod Additive effects on heart rate Details Disopyramide Pacritinib Vonjo® An increased risk of QT interval prolongation Details Disopyramide Paliperidone Erzofri An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Disopyramide Panobinostat Farydak Increased risk of QT interval prolongation Details Disopyramide Paritaprevir Increased exposure of antiarrhythmic drug Details Disopyramide Paroxetine Paxil An increased risk of QT interval prolongation Details Disopyramide Pasireotide Signifor Increased risk of QT prolongation Details Disopyramide Pazopanib Votrient Increased risk of QT interval prolongation Details Disopyramide Pentamidine NebuPent An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Disopyramide Phenobarbital Fidoquel An increased risk of QT interval prolongation, reduced disopyramide exposure and reduced disopyramide efficacy Details Disopyramide Phenytoin Dilantin Reduced disopyramide exposure Details Disopyramide Pimavanserin Nuplazid An increased risk of QT interval prolongation Details Disopyramide Pirmenol An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.