Disopyramide

284 interactions 642 cited references

Also sold as: Norpace Norpace® Norpace® CR

About Disopyramide

Disopyramide is used to treat certain types of irregular heartbeats). Disopyramide is in a class of medications called antiarrhythmic medications. It works by making your heart more resistant to abnormal activity. Read the full Disopyramide drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Levomethadyl Levoketoconazole Mesoridazine Itraconazole Pimozide Piperaquine

15 Contraindicated 247 Major 22 Moderate

All (284) Contraindicated (15) Major (247) Moderate (22)

Major

Disopyramide Tamoxifen Nolvadex® An increased risk of QT interval prolongation Details Disopyramide Telavancin Vibativ An increased risk of QT interval prolongation Details Disopyramide Telithromycin An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Disopyramide Tetrabenazine Xenazine Increased risk of QT interval prolongation Details Disopyramide Tolazamide Tolinase® Increased risk of hypoglycemia Details Disopyramide Tolbutamide Orinase® Increased risk of hypoglycemia Details Disopyramide Toremifene Fareston An increased risk of QT interval prolongation, ventricular tachycardia or an increased risk of torsade de pointes Details Disopyramide Trazodone Raldesy An increased risk of QT interval prolongation and an increased risk of cardiac arrythmia Details Disopyramide Triclabendazole Egaten An increased risk of QT interval prolongation Details Disopyramide Trifluoperazine An increased risk of QT interval prolongation Details Disopyramide Trimethoprim Primsol An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Disopyramide Trimipramine An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Disopyramide Triptorelin Increased risk of QT interval prolongation Details Disopyramide Vandetanib Caprelsa An increased risk of QT interval prolongation and Torsades de pointes Details Disopyramide Vardenafil Levitra An increased risk of QT interval prolongation Details Disopyramide Vemurafenib Zelboraf Increased risk of QT interval prolongation Details Disopyramide Venlafaxine An increased risk of QT interval prolongation Details Disopyramide Vepdegestrant Veppanu An increased risk of QT interval prolongation and an increased risk of torsade de pointes, polymorphic ventricular tachycardia, ot... Details Disopyramide Vilanterol An increased risk of QT interval prolongation Details Disopyramide Vinflunine Increased risk of QT-interval prolongation Details Disopyramide Voclosporin Lupkynis An increased risk of QT interval prolongation Details Disopyramide Voriconazole Vfend An increased risk of QT interval prolongation Details Disopyramide Ziftomenib Komzifti An increased risk of QT interval prolongation and torsade de pointes Details Disopyramide Zolmitriptan Zomig An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Disopyramide Zotepine An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Disopyramide Zuclopenthixol An increased risk of QT interval prolongation Details Disopyramide Dolasetron Injection Anzemet Cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Disopyramide Foscarnet Injection Foscavir An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Disopyramide Gatifloxacin Ophthalmic Zymar® An increased risk of QT interval prolongation Details Disopyramide Goserelin Implant Zoladex Increased risk of QT interval prolongation Details Disopyramide Granisetron Transdermal Patch Sancuso An increased risk of QT interval prolongation Details Disopyramide Granisetron Injection Granisol An increased risk of QT interval prolongation Details Disopyramide Histrelin Implant Supprelin Increased risk of QT interval prolongation Details Disopyramide Inotuzumab Ozogamicin Injection Besponsa Increased risk of QT interval prolongation Details Disopyramide Ketoconazole Topical Extina® Foam Increased risk for QT interval prolongation Details Disopyramide Lacosamide Injection Motpoly An increased risk of AV block, bradycardia, and ventricular tachyarrhythmia Details Disopyramide Levofloxacin Injection Levaquin Increased risk of QT interval prolongation Details Disopyramide Metronidazole Injection Flagyl An increased risk of QT interval prolongation Details Disopyramide Metronidazole Topical MetroCream® An increased risk of QT interval prolongation Details Disopyramide Metronidazole Vaginal MetroGel® Vaginal An increased risk of QT interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.