Disulfiram

Contraindicated

Disulfiram Sertraline An increased risk of a disulfiram-alcohol reaction Details Disulfiram Amprenavir An increased risk of propylene glycol toxicity (seizures, tachycardia, lactic acidosis, renal toxicity, hemolysis) Details Disulfiram Dronabinol Marinol Disulfiram-like reaction Details Disulfiram Metronidazole Flagyl An increased risk of psychotic reactions Details Disulfiram Paraldehyde Disulfiram-ethanol type reaction Details Disulfiram Metronidazole Injection Flagyl An increased risk of psychotic reactions Details Disulfiram Metronidazole Topical MetroCream® An increased risk of psychotic reactions Details Disulfiram Metronidazole Vaginal MetroGel® Vaginal An increased risk of psychotic reactions Details

Major

Disulfiram Omeprazole Gastrobim Altered disulfiram exposure and an increased risk of disulfiram toxicity (confusion, disorientation, psychotic changes) Details Disulfiram Azathioprine Azasan An increased risk of hepatotoxicity Details Disulfiram Bupropion Aplenzin Increased buPROPion exposure and reduced hydroxybuPROPion exposure Details Disulfiram Clomipramine Anafranil Increased clomiPRAMINE exposure Details Disulfiram Fexinidazole CNS toxicity (psychotic symptoms) Details Disulfiram Fosphenytoin Cerebyx Increased phenytoin or fosphenytoin (prodrug of phenytoin) exposure and an increased risk of phenytoin or fosphenytoin toxicity (a... Details Disulfiram Isocarboxazid Marplan An increased risk of severe toxicity, including convulsions Details Disulfiram Levoketoconazole Recorlev Increased risk of serious hepatotoxicity and drug-induced liver injury Details Disulfiram Meloxicam Alloxate Increased meloxicam exposure and reduced meloxicam metabolic clearance Details Disulfiram Meperidine Demerol Increased meperidine exposure and an increased risk of meperidine-related adverse effects Details Disulfiram Mercaptopurine Purinethol® An increased risk of hepatotoxicity Details Disulfiram Methadone Diskets Increased methadone exposure and an increased risk of opioid adverse effects Details Disulfiram Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Disulfiram Phenobarbital Fidoquel Increased PHENobarbital exposure and an increased risk of PHENobarbital-related adverse effects Details Disulfiram Phenytoin Dilantin Increased phenytoin or fosphenytoin (prodrug of phenytoin) exposure and an increased risk of phenytoin or fosphenytoin toxicity (a... Details Disulfiram Pimozide Increased pimozide exposure and an increased risk of pimozide-related adverse reactions Details Disulfiram Primidone Mysoline Increased PHENobarbital exposure and an increased risk of PHENobarbital-related adverse effects Details Disulfiram Secnidazole Solosec Risk of sudden psychiatric symptoms (eg, delirium, confusion) Details Disulfiram Tinidazole Tindamax CNS toxicity (psychotic symptoms, confusion) Details Disulfiram Tizanidine Increased tiZANidine exposure and an increased risk of tiZANidine-related hypotension, bradycardia or increased drowsiness Details Disulfiram Tranylcypromine Parnate An increased risk of delirium (agitation, disorientation, hallucinations) Details Disulfiram Voriconazole Vfend Increased voriconazole exposure Details Disulfiram Warfarin Coumadin Increased warfarin exposure, an increased risk of bleeding and an increased INR Details Disulfiram Meloxicam Injection Alloxate Increased meloxicam exposure and reduced meloxicam metabolic clearance Details Disulfiram Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details

Moderate

Disulfiram Amitriptyline Elavil An increased risk of a psychotic and confusional mental state Details Disulfiram Diazepam Nasal Spray Valtoco An increased risk of central nervous system depression Details Disulfiram Diazepam Rectal Diastat An increased risk of central nervous system depression Details Disulfiram Anisindione Increased risk of bleeding Details Disulfiram Diazepam Diastat An increased risk of central nervous system depression Details Disulfiram Dicumarol An increased risk of bleeding Details Disulfiram Isoniazid Increased risk of disulfiram CNS effects (changes in behavior, coordination, and mood) Details