Disulfiram

Name: Disulfiram Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

45 interactions 184 cited references

Also sold as: Antabuse Antabuse®

About Disulfiram

Disulfiram is a medication used to discourage drinking in people with chronic alcoholism. Read the full Disulfiram drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Metronidazole Injection Metronidazole Vaginal Metronidazole Topical Amprenavir Paraldehyde Metronidazole

8 Contraindicated 25 Major 9 Moderate 3 Minor

All (45) Contraindicated (8) Major (25) Moderate (9) Minor (3)

Contraindicated

Disulfiram Sertraline An increased risk of a disulfiram-alcohol reaction Details Disulfiram Amprenavir An increased risk of propylene glycol toxicity (seizures, tachycardia, lactic acidosis, renal toxicity, hemolysis) Details Disulfiram Dronabinol Marinol Disulfiram-like reaction Details Disulfiram Metronidazole Flagyl An increased risk of psychotic reactions Details Disulfiram Paraldehyde Disulfiram-ethanol type reaction Details Disulfiram Metronidazole Injection Flagyl An increased risk of psychotic reactions Details Disulfiram Metronidazole Topical MetroCream® An increased risk of psychotic reactions Details Disulfiram Metronidazole Vaginal MetroGel® Vaginal An increased risk of psychotic reactions Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.