Disulfiram

Name: Disulfiram Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

45 interactions 184 cited references

Also sold as: Antabuse Antabuse®

About Disulfiram

Disulfiram is a medication used to discourage drinking in people with chronic alcoholism. Read the full Disulfiram drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Metronidazole Injection Metronidazole Vaginal Metronidazole Topical Amprenavir Paraldehyde Metronidazole

8 Contraindicated 25 Major 9 Moderate 3 Minor

All (45) Contraindicated (8) Major (25) Moderate (9) Minor (3)

Moderate

Disulfiram Amitriptyline Elavil An increased risk of a psychotic and confusional mental state Details Disulfiram Diazepam Nasal Spray Valtoco An increased risk of central nervous system depression Details Disulfiram Diazepam Rectal Diastat An increased risk of central nervous system depression Details Disulfiram Anisindione Increased risk of bleeding Details Disulfiram Diazepam Diastat An increased risk of central nervous system depression Details Disulfiram Dicumarol An increased risk of bleeding Details Disulfiram Isoniazid Increased risk of disulfiram CNS effects (changes in behavior, coordination, and mood) Details Disulfiram Phenprocoumon Increased risk of bleeding Details Disulfiram Theophylline Accurbron® Theophylline toxicity (nausea, vomiting, palpitations, seizures) Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.